{"id":"W2144144716","doi":"10.1152/ajpgi.00407.2007","title":"Tumor necrosis factor-α directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Endocrinology; Internal medicine; Very low-density lipoprotein; Insulin resistance; Microsomal triglyceride transfer protein; Apolipoprotein B; Insulin receptor; Insulin; Tumor necrosis factor alpha; Biology; Lipoprotein; Chemistry; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162081,0.0003781005,0.0002071498,0.0001482729,0.00007216228,0.0002283555,0.0000826813,0.0001055688,0.0008461605],"category_scores_gemma":[0.0000832468,0.0001096492,0.0002127652,0.00009820929,0.0002009493,0.0001040249,0.0001345054,0.0004025412,0.0002364402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002247701,"about_ca_system_score_gemma":0.00008109815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003500992,"about_ca_topic_score_gemma":0.0003996548,"domain_scores_codex":[0.9999179,0.00001655189,0.00001071442,0.00001726493,0.0000191021,0.00001856351],"domain_scores_gemma":[0.9999059,0.0000107626,0.00003222606,0.00001822114,0.000007778275,0.00002511154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002820886,0.00003191772,0.0004252217,0.00002551351,0.000006328855,0.00005231988,0.000005994566,0.00002275447,0.9984345,0.0000169956,0.00001415205,0.0006821915],"study_design_scores_gemma":[0.00006078595,0.001235112,0.01022201,0.000007414028,0.00002482414,0.0003338837,0.00002518031,0.0006212216,0.986407,0.00003549436,0.001024132,0.000002930726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975123,0.0009490058,0.0008097576,0.00004620213,0.00003067902,0.00001158492,0.0001119491,0.00003902039,0.0004894714],"genre_scores_gemma":[0.9970721,0.0009123215,0.0006560272,0.00003529084,0.0000162541,0.00001642263,0.0002793436,0.000007286998,0.001004892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008461605,"threshold_uncertainty_score":0.002830625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102191150397496,"score_gpt":0.2290447955011883,"score_spread":0.2188256804614387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}