{"id":"W2144146259","doi":"10.1016/j.beem.2007.08.004","title":"Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus","year":2007,"lang":"en","type":"review","venue":"Best Practice & Research Clinical Endocrinology & Metabolism","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University Health Network; University of Toronto","funders":"","keywords":"Insulin resistance; Insulin receptor; Protein tyrosine phosphatase; Insulin; Endocrinology; Internal medicine; Type 2 diabetes; Type 2 Diabetes Mellitus; Phosphorylation; IRS1; Dephosphorylation; Diabetes mellitus; Biology; Medicine; Phosphatase; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006164425,0.001097705,0.001771235,0.001211383,0.0002542216,0.0007530302,0.001146766,0.001304135,0.002849231],"category_scores_gemma":[0.0004832507,0.0002795641,0.0004735032,0.001192774,0.0005241937,0.0009131169,0.0005339404,0.00287592,0.00245808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005150955,"about_ca_system_score_gemma":0.0005937424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008044492,"about_ca_topic_score_gemma":0.002108288,"domain_scores_codex":[0.9998416,0.00002073656,0.00001553921,0.00002840128,0.00007456014,0.00001921712],"domain_scores_gemma":[0.9998216,0.00007247785,0.0000263478,0.000005623494,0.00004567726,0.00002835887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002370369,0.0001907035,0.000150132,0.004721113,0.0001019014,0.0003572755,0.0000310237,0.0005112128,0.004704508,0.002785706,0.05052899,0.9356804],"study_design_scores_gemma":[0.0002033556,0.0002610397,0.0009198721,0.0009170442,0.0001555416,0.001898043,0.0000313594,0.0002544474,0.001657025,0.00185476,0.9918211,0.00002657425],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00033589,0.9967307,0.0005334292,0.0005227746,0.0005108613,0.000009692485,0.00002501233,0.00002060899,0.001311071],"genre_scores_gemma":[0.001577978,0.9954579,0.0005752985,0.0004617659,0.0003078796,0.00001766597,0.00005637627,0.000003276564,0.0015419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002849231,"threshold_uncertainty_score":0.009531617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1031528505575023,"score_gpt":0.4516923393027854,"score_spread":0.3485394887452831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}