{"id":"W2144190398","doi":"10.1124/mol.63.3.617","title":"Erythromycin, Roxithromycin, and Clarithromycin: Use of Slow-Binding Kinetics to Compare Their in Vitro Interaction with a Bacterial Ribosomal Complex Active in Peptide Bond Formation","year":2003,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Roxithromycin; Clarithromycin; In vitro; Erythromycin; Kinetics; Ribosomal RNA; Chemistry; 23S ribosomal RNA; Microbiology; Peptide; Biochemistry; Biology; Antibiotics; Ribosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001692301,0.0002578881,0.0003760953,0.0002150753,0.00004110751,0.00002608507,0.0001146645,0.0001329952,0.00004083406],"category_scores_gemma":[0.00004325827,0.0002488061,0.00005985105,0.0002031951,0.00007669642,0.00003321996,0.00008351733,0.0001663545,0.000002039954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006613931,"about_ca_system_score_gemma":0.00004521144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006057055,"about_ca_topic_score_gemma":0.0001793943,"domain_scores_codex":[0.9983926,0.0003600093,0.000383628,0.0004040009,0.0001131851,0.0003465166],"domain_scores_gemma":[0.9994158,0.00004370448,0.0001722736,0.0001858695,0.00008498723,0.00009740446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00155041,0.000174855,0.000272611,0.00003451156,0.00006813138,0.00002381934,0.0002596046,0.0005977504,0.9959897,0.00004231689,0.0001284691,0.0008578069],"study_design_scores_gemma":[0.002067544,0.000623673,0.001873794,0.00004568048,0.00003417206,0.0001028007,0.0003580859,0.0001420996,0.989461,0.00003068702,0.004999699,0.0002607379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931729,0.00006255494,0.005523249,0.0001579656,0.0001371028,0.0007470498,0.00005099376,0.000007806047,0.0001404016],"genre_scores_gemma":[0.9917808,0.00003134577,0.007514777,0.0003529828,0.00003404967,0.00009072049,0.0001508866,0.00003260625,0.00001182681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006528688,"threshold_uncertainty_score":0.9999964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547239162185119,"score_gpt":0.270914167369637,"score_spread":0.2454417757477858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}