{"id":"W2144206107","doi":"10.1128/mcb.22.20.7325-7336.2002","title":"The Pleckstrin Homology (PH) Domain-Interacting Protein Couples the Insulin Receptor Substrate 1 PH Domain to Insulin Signaling Pathways Leading to Mitogenesis and GLUT4 Translocation","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University; University of Toronto; Hamilton Regional Laboratory Medicine Program","funders":"National Institutes of Health","keywords":"GLUT4; Pleckstrin homology domain; Biology; Insulin receptor; IRS1; Insulin receptor substrate; Signal transduction; Cell biology; Phosphotyrosine-binding domain; Insulin; Biochemistry; Molecular biology; Tyrosine kinase; Glucose transporter; Endocrinology; Insulin resistance; SH2 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006731665,0.0003487394,0.0003011787,0.00008631421,0.0005524274,0.00008896945,0.0003091065,0.0003162373,0.00002476992],"category_scores_gemma":[0.00007232824,0.0002614715,0.0001303628,0.0002275795,0.0002249978,0.000007801532,0.0000921867,0.0002298548,0.00002079859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002205282,"about_ca_system_score_gemma":0.00003230352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006839086,"about_ca_topic_score_gemma":0.0001769784,"domain_scores_codex":[0.9977543,0.0003588288,0.00048228,0.0007226287,0.0001312156,0.0005507604],"domain_scores_gemma":[0.99911,0.00006097569,0.0001284396,0.0004161422,0.00009141929,0.0001930139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002062163,0.00004133268,0.0002938962,0.00001940148,0.00008052658,0.00002045402,0.0007816406,0.00006880039,0.9893923,0.0008815909,0.00001628433,0.008197591],"study_design_scores_gemma":[0.00070268,0.0005712877,0.0001045129,0.00004001442,0.00003313541,0.00004596688,0.0006662321,0.0001029698,0.9538007,0.0004610673,0.04307394,0.0003974677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9174817,0.01068574,0.06890608,0.001828644,0.0001518721,0.0008222638,0.00002708242,0.00002267048,0.00007397153],"genre_scores_gemma":[0.9966971,0.0007295106,0.001268542,0.000387961,0.0001734095,0.0001534353,0.0004562136,0.00004586212,0.00008795379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07921542,"threshold_uncertainty_score":0.9999837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200541623149028,"score_gpt":0.2098825104142397,"score_spread":0.1978770941827494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}