{"id":"W2144206107","doi":"10.1128/mcb.22.20.7325-7336.2002","title":"The Pleckstrin Homology (PH) Domain-Interacting Protein Couples the Insulin Receptor Substrate 1 PH Domain to Insulin Signaling Pathways Leading to Mitogenesis and GLUT4 Translocation","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University; University of Toronto; Hamilton Regional Laboratory Medicine Program","funders":"National Institutes of Health","keywords":"GLUT4; Pleckstrin homology domain; Biology; Insulin receptor; IRS1; Insulin receptor substrate; Signal transduction; Cell biology; Phosphotyrosine-binding domain; Insulin; Biochemistry; Molecular biology; Tyrosine kinase; Glucose transporter; Endocrinology; Insulin resistance; SH2 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007462779,0.000425542,0.0001347752,0.0001809596,0.0001283709,0.0002074431,0.0001658815,0.0002101929,0.001184113],"category_scores_gemma":[0.00005661691,0.000163758,0.0001684451,0.0001674021,0.0001734538,0.0002075666,0.0003206591,0.0003259401,0.0007182365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794174,"about_ca_system_score_gemma":0.00007152015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001451897,"about_ca_topic_score_gemma":0.0001721671,"domain_scores_codex":[0.9999441,0.000007936506,0.000003317059,0.00001611753,0.00001578814,0.00001274702],"domain_scores_gemma":[0.9999706,0.000004671036,0.00001051108,0.000003179018,0.00000192046,0.000009228272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000458382,0.0000101138,0.0002083223,0.00003322176,0.00000357296,0.00008225444,0.000004271993,0.00004260879,0.9979898,0.0001266556,0.00005322408,0.001400234],"study_design_scores_gemma":[0.00002716596,0.0001564895,0.01807179,0.000008671705,0.0000230763,0.00140913,0.00002670564,0.00161681,0.9692426,0.0001609543,0.009249379,0.000007065703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860596,0.003160308,0.006672652,0.0002011507,0.00003883164,0.00004097349,0.0005396187,0.0001011953,0.003185804],"genre_scores_gemma":[0.9888868,0.002640541,0.002914425,0.00009879835,0.00002304772,0.00002784217,0.001124934,0.00001268362,0.004271006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184113,"threshold_uncertainty_score":0.003961205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200541623149028,"score_gpt":0.2098825104142397,"score_spread":0.1978770941827494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}