{"id":"W2144226378","doi":"10.1634/theoncologist.2011-0011","title":"<i>KRAS</i> and Colorectal Cancer: Ethical and Pragmatic Issues in Effecting Real-Time Change in Oncology Clinical Trials and Practice","year":2011,"lang":"en","type":"article","venue":"The Oncologist","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; U.S. Food and Drug Administration; National Comprehensive Cancer Network","keywords":"Panitumumab; KRAS; Medicine; Cetuximab; Colorectal cancer; Timeline; Clinical trial; Vetting; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.5901016,0.0009172318,0.002850652,0.002326631,0.005811036,0.02233245,0.007352832,0.05112738,0.001957817],"category_scores_gemma":[0.6908421,0.001432915,0.002352771,0.002355026,0.04074131,0.01797349,0.0080512,0.04824681,0.0010812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0113138,"about_ca_system_score_gemma":0.0336897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003333723,"about_ca_topic_score_gemma":0.008480855,"domain_scores_codex":[0.2950803,0.6141213,0.03892182,0.007856782,0.03943374,0.004586071],"domain_scores_gemma":[0.1416422,0.7774955,0.02409264,0.01957072,0.02813385,0.0090651],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009337969,0.0001892458,0.003659404,0.003718075,0.0005251806,0.002284729,0.01666166,0.001978471,0.001219969,0.3380089,0.492869,0.1379515],"study_design_scores_gemma":[0.0008396165,0.0006564157,0.004138509,0.008517218,0.0003087404,0.00180107,0.01001392,0.00425775,0.001140405,0.369639,0.5981954,0.0004919224],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.001142186,0.004978897,0.003660561,0.9783132,0.008766402,0.000141424,0.0000146392,0.0000342423,0.002948418],"genre_scores_gemma":[0.0404101,0.003436138,0.01540845,0.9068704,0.03056641,0.0008410615,0.00001605898,0.00009482606,0.002356665],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5901016,"threshold_uncertainty_score":0.5054778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2411308641853301,"score_gpt":0.5272951237733174,"score_spread":0.2861642595879873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}