{"id":"W2144226378","doi":"10.1634/theoncologist.2011-0011","title":"<i>KRAS</i> and Colorectal Cancer: Ethical and Pragmatic Issues in Effecting Real-Time Change in Oncology Clinical Trials and Practice","year":2011,"lang":"en","type":"article","venue":"The Oncologist","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; U.S. Food and Drug Administration; National Comprehensive Cancer Network","keywords":"Panitumumab; KRAS; Medicine; Cetuximab; Colorectal cancer; Timeline; Clinical trial; Vetting; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01018777,0.0001766829,0.001142777,0.00006254479,0.0001055537,0.00001618817,0.00005081556,0.0003375254,0.00003575424],"category_scores_gemma":[0.007443794,0.0001041015,0.00004133045,0.000146231,0.0007113165,0.00007370645,0.0001348241,0.0006626331,0.000002949946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946083,"about_ca_system_score_gemma":0.000135129,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01244284,"about_ca_topic_score_gemma":0.01315157,"domain_scores_codex":[0.9958857,0.002783644,0.0006176321,0.0003379456,0.0001175428,0.0002575432],"domain_scores_gemma":[0.987373,0.01208965,0.0002826637,0.0001077531,0.00004849995,0.00009843065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02243184,0.001638781,0.5134592,0.0003181158,0.0005417898,0.001015551,0.04902834,2.030625e-7,0.001392952,0.0008137624,0.001434518,0.4079249],"study_design_scores_gemma":[0.009105554,0.009732413,0.9686298,0.0003241489,0.0006617689,0.0003843194,0.003043715,0.0001650981,0.0001401597,0.0004452636,0.007153212,0.0002145471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545581,0.006574801,3.622661e-7,0.02758857,0.000158111,0.001624048,0.00000688675,0.00003050177,0.00945859],"genre_scores_gemma":[0.9537882,0.04275358,0.0006361672,0.001972574,0.0002309655,0.0005320886,0.000002303848,0.000013515,0.00007060681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4551706,"threshold_uncertainty_score":0.9941334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2411308641853301,"score_gpt":0.5272951237733174,"score_spread":0.2861642595879873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}