{"id":"W2144247882","doi":"10.1093/hmg/ddr388","title":"Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; U.S. Forest Service; Institut National Du Cancer; Max-Planck-Gesellschaft; Institut National de la Santé et de la Recherche Médicale; ZonMw; Canadian Institutes of Health Research; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Ligue Contre le Cancer; National Institute for Health and Care Research; National Institutes of Health; National Health and Medical Research Council; Cancer Research UK; Canadian Breast Cancer Research Alliance","keywords":"Biology; Allele; Genetics; Mutation; Breast cancer; Cancer; Allele frequency; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273285,0.0001759249,0.0001831171,0.00005103898,0.0001003063,0.000008519949,0.0005472591,0.0001641076,0.00006361085],"category_scores_gemma":[0.00003286823,0.0001336872,0.0001240792,0.0002626078,0.0003167135,0.00000315531,0.0001772847,0.0001644203,0.000001145364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005011273,"about_ca_system_score_gemma":0.0002284657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009826804,"about_ca_topic_score_gemma":0.001677475,"domain_scores_codex":[0.9986153,0.0002539133,0.0003872265,0.0002902985,0.0002369279,0.0002163469],"domain_scores_gemma":[0.9985741,0.000009311291,0.0003212838,0.0008392879,0.0002155461,0.00004047389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001116987,0.0001554254,0.07029889,0.00004558283,0.0004049763,0.000004981722,0.002557577,0.02805555,0.8938736,0.0005464689,0.0004546271,0.003490578],"study_design_scores_gemma":[0.0007296235,0.000141704,0.581995,0.00002791631,0.0001576989,0.00001616461,0.0002900572,0.0005494409,0.4139224,0.001654316,0.0003108107,0.000204886],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963171,0.001701898,0.0004201518,0.0000602092,0.0001695118,0.0003731055,0.0001305836,0.000004209344,0.0008232311],"genre_scores_gemma":[0.9988829,0.000338192,0.0004577588,0.0001272625,0.00004697989,0.00003231162,0.0000293737,0.00003803151,0.00004714756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5116962,"threshold_uncertainty_score":0.5451606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617905330210621,"score_gpt":0.2675684263447701,"score_spread":0.2513893730426639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}