{"id":"W2144282451","doi":"10.1152/ajpgi.00330.2007","title":"Prostaglandin E<sub>2</sub>modulates TNF-α-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Universität Zürich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Endocrinology; Internal medicine; Prostaglandin E; Inflammation; Downregulation and upregulation; Prostaglandin; Monocyte; Pancreatitis; Tumor necrosis factor alpha; Receptor; Pancreas; Chemistry; Ceruletide; Acinar cell; Prostaglandin E2; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005402151,0.0004022508,0.001393817,0.0005276429,0.0000667147,0.000007628003,0.0001510802,0.0001013224,0.00002024894],"category_scores_gemma":[0.0002014237,0.0003062127,0.0001781464,0.0003300757,0.0006656725,0.0001268049,0.00008383606,0.0007128623,0.00001554357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001589738,"about_ca_system_score_gemma":0.0001146944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001820565,"about_ca_topic_score_gemma":0.00008089973,"domain_scores_codex":[0.9975149,0.0003906403,0.000686481,0.0005038802,0.0001658182,0.000738269],"domain_scores_gemma":[0.9980016,0.000737554,0.0006296338,0.0002424079,0.0001387449,0.0002500396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003080443,0.0006750885,0.08400894,0.00006473641,0.0001078029,0.001834292,0.0002989554,0.00002664463,0.9047508,0.00004691366,0.00001688904,0.005088527],"study_design_scores_gemma":[0.002059247,0.006271531,0.8556065,0.0005507991,0.0001587786,0.005774059,0.0007764008,0.00006466388,0.1281586,0.0003668038,0.000005404605,0.0002072219],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989614,0.0002202011,0.00003819658,0.0003222293,0.00007958162,0.0002981059,0.00001099501,0.00001690065,0.00005232697],"genre_scores_gemma":[0.9972563,0.0002855702,0.001989692,0.0002066029,0.0001872767,0.00002115749,0.000008324999,0.00002819933,0.00001688229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7765922,"threshold_uncertainty_score":0.999939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009326028307452683,"score_gpt":0.2342699636885785,"score_spread":0.2249439353811258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}