{"id":"W2144290097","doi":"10.2174/187152008784220311","title":"Polynucleotide Kinase as a Potential Target for Enhancing Cytotoxicity by Ionizing Radiation and Topoisomerase I Inhibitors","year":2008,"lang":"en","type":"review","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"DNA repair; DNA damage; Biology; Topoisomerase; Biochemistry; Cell biology; DNA; DNA polymerase beta; DNA repair protein XRCC4; DNA polymerase; Base excision repair; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721815,0.0004857358,0.0004508499,0.0003242692,0.0001866093,0.0004810838,0.0002913109,0.0003925614,0.002006914],"category_scores_gemma":[0.0001408402,0.0001757989,0.0003485833,0.0002618895,0.000136651,0.000362456,0.000201378,0.0008241534,0.0006097014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005862229,"about_ca_system_score_gemma":0.0003633829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000607369,"about_ca_topic_score_gemma":0.001259022,"domain_scores_codex":[0.9998912,0.00001346755,0.000007161709,0.00003294782,0.00003160491,0.00002369423],"domain_scores_gemma":[0.9999309,0.00001013457,0.00001548409,0.000004904985,0.000020689,0.00001784276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001989954,0.00009750557,0.0002787499,0.0003357658,0.00002168656,0.00008083326,0.00001766879,0.0004663245,0.9863397,0.0004307581,0.0002511627,0.01148099],"study_design_scores_gemma":[0.00008060788,0.001372438,0.002582449,0.00004004409,0.00008917341,0.0003909582,0.00002645395,0.002007406,0.9653025,0.000227057,0.02786224,0.00001871192],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8343208,0.1130632,0.02895389,0.001391806,0.0007855133,0.0005574668,0.001303471,0.0007312606,0.01889262],"genre_scores_gemma":[0.9521275,0.02614596,0.0100735,0.00027912,0.00008005773,0.0002279661,0.001395392,0.00004591182,0.009624659],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002006914,"threshold_uncertainty_score":0.006713808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999890104138465,"score_gpt":0.3268092932797799,"score_spread":0.3068103922383953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}