{"id":"W2144290097","doi":"10.2174/187152008784220311","title":"Polynucleotide Kinase as a Potential Target for Enhancing Cytotoxicity by Ionizing Radiation and Topoisomerase I Inhibitors","year":2008,"lang":"en","type":"review","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"DNA repair; DNA damage; Biology; Topoisomerase; Biochemistry; Cell biology; DNA; DNA polymerase beta; DNA repair protein XRCC4; DNA polymerase; Base excision repair; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002022039,0.0005028418,0.0008913526,0.00006521504,0.000152614,0.00003071683,0.0002459269,0.0005152716,0.00006480773],"category_scores_gemma":[0.00006498557,0.0004968098,0.0002828154,0.0001427857,0.0001109349,0.00000855159,0.0001151884,0.0003398173,0.00000156605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001633135,"about_ca_system_score_gemma":0.0004185093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001194787,"about_ca_topic_score_gemma":0.00001035091,"domain_scores_codex":[0.9977778,0.00004809272,0.0006269866,0.0007997061,0.0002721218,0.0004752914],"domain_scores_gemma":[0.9990421,0.00002068767,0.0003782824,0.0003110449,0.00005484592,0.0001930212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001216164,0.0001743539,0.00003760451,0.007753127,0.0004385623,0.0000619874,0.00009484007,0.00001299911,0.4889549,0.000002671023,0.004979007,0.4973684],"study_design_scores_gemma":[0.001072667,0.000123733,0.000002225846,0.001935979,0.0002093939,0.00008301238,0.00005351099,0.00002363051,0.3625613,0.00001230323,0.6334055,0.000516758],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03973984,0.9583141,0.0004938816,0.00004247038,0.0004027905,0.0006714431,0.0002628729,0.00001329863,0.00005936115],"genre_scores_gemma":[0.01945138,0.9772445,0.00011818,0.0002710407,0.00121009,0.0002684264,0.0008730427,0.00008451541,0.0004788448],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6284265,"threshold_uncertainty_score":0.9997483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999890104138465,"score_gpt":0.3268092932797799,"score_spread":0.3068103922383953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}