{"id":"W2144290541","doi":"10.1016/j.atherosclerosis.2014.05.943","title":"Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells","year":2014,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; University of Saskatchewan","funders":"Natural Science Foundation of Hunan Province","keywords":"ABCA1; TLR2; Chlamydophila pneumoniae; THP1 cell line; Macrophage; Efflux; Biology; Chemistry; Microbiology; Cell biology; Chlamydia; Signal transduction; Immunology; TLR4; Transporter; Cell culture; Biochemistry; Gene; Chlamydiaceae; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004828878,0.0003878541,0.0005027527,0.0002391766,0.0004282613,0.00008092424,0.0003434305,0.0004613546,0.0004573424],"category_scores_gemma":[0.000199555,0.000343696,0.0001148653,0.0003028895,0.0004961155,0.0003107889,0.0002755884,0.0007129824,0.0009212907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001028972,"about_ca_system_score_gemma":0.00002860785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004969778,"about_ca_topic_score_gemma":0.00004917708,"domain_scores_codex":[0.9971209,0.000723087,0.0004433896,0.0009060455,0.0001067417,0.000699815],"domain_scores_gemma":[0.9986112,0.0003300293,0.0001607029,0.0007032407,0.000117865,0.00007698876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000779016,0.0002526184,0.01098553,0.00002578627,0.00005180235,0.000001164566,0.001691446,0.00002527803,0.9815747,0.00005837881,0.0001747874,0.005080595],"study_design_scores_gemma":[0.0009827327,0.0002421374,0.3150234,0.00007595093,0.00001059671,0.000009135611,0.0001567289,0.00005816355,0.6810532,0.0002938545,0.00180471,0.0002893808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977252,0.0003558609,0.0001497326,0.0001804108,0.0003583445,0.0005610727,0.00005215742,0.000222253,0.0003948992],"genre_scores_gemma":[0.9986696,0.0003826659,0.0002018641,0.00006018086,0.00005762061,0.00007176626,0.00001766969,0.0001046806,0.0004339328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3040379,"threshold_uncertainty_score":0.9999015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857328959350711,"score_gpt":0.2282172541896978,"score_spread":0.2096439645961907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}