{"id":"W2144290541","doi":"10.1016/j.atherosclerosis.2014.05.943","title":"Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells","year":2014,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; University of Saskatchewan","funders":"Natural Science Foundation of Hunan Province","keywords":"ABCA1; TLR2; Chlamydophila pneumoniae; THP1 cell line; Macrophage; Efflux; Biology; Chemistry; Microbiology; Cell biology; Chlamydia; Signal transduction; Immunology; TLR4; Transporter; Cell culture; Biochemistry; Gene; Chlamydiaceae; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232893,0.0003423857,0.0003607472,0.0003408866,0.0004627147,0.0005218322,0.0001354132,0.0003824813,0.001537543],"category_scores_gemma":[0.0002911432,0.000329708,0.0003947192,0.0001902821,0.0002921364,0.000262717,0.0003955048,0.0007408487,0.0005348537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003405413,"about_ca_system_score_gemma":0.000587613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002014712,"about_ca_topic_score_gemma":0.00244546,"domain_scores_codex":[0.9994641,0.00008138845,0.00004134345,0.00006068001,0.0001250665,0.0002273833],"domain_scores_gemma":[0.9998083,0.00003133651,0.0000530101,0.00001920076,0.0000475886,0.00004067958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009612505,0.00007156206,0.001945081,0.0001594249,0.0000189226,0.00019138,0.00007821435,0.0000434862,0.9936528,0.0001446597,0.0003340197,0.002399167],"study_design_scores_gemma":[0.0001639991,0.000628316,0.1542303,0.0000793388,0.0001861031,0.001169445,0.0006543517,0.002640739,0.8307599,0.0003165832,0.009128855,0.00004201273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900289,0.004752208,0.001696475,0.0003800106,0.0001714569,0.00003134572,0.001079254,0.00009247728,0.001767859],"genre_scores_gemma":[0.9930737,0.001593734,0.001532943,0.0001774445,0.00003077672,0.00006861699,0.0007034747,0.00001852896,0.002800877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002014712,"threshold_uncertainty_score":0.005143583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857328959350711,"score_gpt":0.2282172541896978,"score_spread":0.2096439645961907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}