{"id":"W2144329580","doi":"10.1186/1477-5751-13-14","title":"Reduction in hSOD1 copy number significantly impacts ALS phenotype presentation in G37R (line 29) mice: implications for the assessment of putative therapeutic agents","year":2014,"lang":"en","type":"article","venue":"Journal of Negative Results in BioMedicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; ALS Society of Canada","keywords":"Reduction (mathematics); Phenotype; Biology; Line (geometry); Presentation (obstetrics); Computational biology; Genetics; Medicine; Gene; Mathematics; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002866995,0.0001756425,0.0005995953,0.0005599587,0.00004479616,0.00001343089,0.0002104372,0.0001073065,0.00002495471],"category_scores_gemma":[0.001502218,0.0001049201,0.00009106539,0.001261649,0.0003147716,0.000199312,0.00003195265,0.0005271524,0.000001266599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005684485,"about_ca_system_score_gemma":0.0002989261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003627415,"about_ca_topic_score_gemma":0.00005754776,"domain_scores_codex":[0.9969415,0.0004431225,0.001451435,0.0002377988,0.0006050739,0.0003210778],"domain_scores_gemma":[0.9962688,0.001689068,0.0009464878,0.000228203,0.0007375403,0.0001299016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01194439,0.002231022,0.1127555,0.0003484212,0.0005338576,0.00002108308,0.01107514,0.002755235,0.8075607,0.0004926177,0.001858588,0.04842347],"study_design_scores_gemma":[0.01348701,0.001894956,0.9696703,0.0007058214,0.00007472489,0.00003086888,0.00138363,0.004405361,0.005633812,0.002473057,0.0001510267,0.0000894331],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529341,0.0001781984,0.004586001,0.03974352,0.0002164402,0.001892165,0.00005299372,0.000005395012,0.000391162],"genre_scores_gemma":[0.9961452,0.0007563629,0.002454066,0.0001592757,0.0003003519,0.00005118605,0.000037989,0.0000205776,0.00007492451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8569148,"threshold_uncertainty_score":0.4278519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08381183165854224,"score_gpt":0.4532519726937338,"score_spread":0.3694401410351916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}