{"id":"W2144359980","doi":"10.1002/emmm.201201429","title":"Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis","year":2013,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Princess Margaret Hospital Foundation; Ellison Medical Foundation; National Institutes of Health; National Center for Research Resources; American Diabetes Association; U.S. Public Health Service; Howard Hughes Medical Institute","keywords":"Mitochondrion; Unfolded protein response; Reactive oxygen species; NAD+ kinase; Homeostasis; Oxidative stress; Chemistry; Cell biology; Redox; Biochemistry; Biology; Endoplasmic reticulum; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003517331,0.0003735831,0.0003508802,0.00008968653,0.0001641665,0.00005597467,0.0002967076,0.0001917868,0.0001609062],"category_scores_gemma":[0.000815093,0.000245235,0.00009944221,0.0002269827,0.0005732849,0.00001109351,0.000202002,0.0001880116,0.00002074156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002136487,"about_ca_system_score_gemma":0.000117922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281366,"about_ca_topic_score_gemma":0.00001483488,"domain_scores_codex":[0.9976782,0.0003048306,0.000403945,0.000623758,0.0004076017,0.0005816485],"domain_scores_gemma":[0.9983043,0.00003873915,0.0001615756,0.0009191922,0.0001753811,0.0004008084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003136714,0.00005864722,0.0003258228,0.00007502651,0.0001165685,0.0001165065,0.0001077604,0.000009578527,0.9920586,0.0002038492,0.004478454,0.00213546],"study_design_scores_gemma":[0.005916218,0.003195194,0.04390553,0.0007522315,0.0002739372,0.0004389627,0.001384151,0.0002201533,0.8996686,0.002971611,0.03998817,0.00128523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981667,0.009704774,0.0001395208,0.006096908,0.00006689332,0.001650065,0.00002535996,0.00003667331,0.0006127641],"genre_scores_gemma":[0.9958695,0.000185276,0.000412811,0.0008215053,0.0001004989,0.000507454,0.0001428771,0.00005819241,0.001901856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09239004,"threshold_uncertainty_score":1,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004521057674887702,"score_gpt":0.2209311951708227,"score_spread":0.216410137495935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}