{"id":"W2144360055","doi":"10.1016/j.bmcl.2004.06.063","title":"Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"DNA gyrase; Chemistry; Antibacterial activity; Antibacterial agent; Gram; Stereochemistry; In vitro; Potency; Structure–activity relationship; Antibiotics; Chemical synthesis; Combinatorial chemistry; Escherichia coli; Bacteria; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346035,0.0002523871,0.0002844016,0.0003250129,0.0001411317,0.0002482715,0.0003112567,0.0001679196,0.002119842],"category_scores_gemma":[0.0002000753,0.000153175,0.0002088584,0.0001662733,0.000171269,0.0001917014,0.0001309017,0.0002770588,0.0003985007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894116,"about_ca_system_score_gemma":0.0002436112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000754566,"about_ca_topic_score_gemma":0.001619663,"domain_scores_codex":[0.9999197,0.00002011549,0.000009617795,0.00001093888,0.00001642828,0.00002318916],"domain_scores_gemma":[0.9999074,0.00002305846,0.00002507769,0.000007451709,0.00001691887,0.00002011798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007688174,0.0002476936,0.0005052743,0.0001737084,0.00002441889,0.0002302889,0.00007721625,0.001340428,0.9785219,0.0006936638,0.0002197789,0.01719684],"study_design_scores_gemma":[0.0002681447,0.005127516,0.005184189,0.00001979689,0.0000845851,0.0003749202,0.0000352342,0.001362688,0.9768266,0.0001690637,0.01052676,0.00002054938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725395,0.01705229,0.003193869,0.0001896246,0.00006066669,0.0001531809,0.0005697036,0.00007863899,0.006162529],"genre_scores_gemma":[0.9925435,0.003315686,0.001539692,0.00006943423,0.00001948482,0.00002556799,0.0004256381,0.000008388864,0.002052594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002119842,"threshold_uncertainty_score":0.007091582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873872148372895,"score_gpt":0.2356754728806598,"score_spread":0.2169367513969309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}