{"id":"W2144367857","doi":"10.1074/jbc.m115.645051","title":"Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; U.S. Department of Veterans Affairs; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Pseudomonas aeruginosa; Guanosine monophosphate; Biology; Cystic fibrosis; Secretion; Mutant; Pathogen; Guanosine; Biochemistry; Microbiology; Chemistry; Gene; Bacteria; Nucleotide; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003946682,0.0001137988,0.0002181245,0.00002718807,0.00002090058,0.000008137552,0.00009746855,0.0002363279,0.00001555759],"category_scores_gemma":[0.0003246895,0.00008861419,0.0001323233,0.00008357231,0.00009119642,0.00001045233,0.00002335961,0.00008942908,3.813182e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001846089,"about_ca_system_score_gemma":0.0001003037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000348215,"about_ca_topic_score_gemma":5.631123e-7,"domain_scores_codex":[0.9990668,0.00003341885,0.0004522841,0.0001821323,0.0001197405,0.0001456069],"domain_scores_gemma":[0.999008,0.00001611176,0.0003696998,0.0001130707,0.0004189084,0.00007421921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008660496,0.00007640568,0.001967331,0.00002487986,0.00002439846,0.000001237111,0.00003671582,0.00005180214,0.9950849,0.000007693269,0.0003334429,0.001525139],"study_design_scores_gemma":[0.0007699904,0.0003799813,0.008402199,0.0000333268,0.00001264719,0.00008439115,0.00006460311,0.00002765884,0.9878174,0.0002284691,0.002068134,0.0001111634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980826,0.0004146399,0.0001817439,0.0008710759,0.0002156235,0.00009528804,0.00001756615,0.00000285907,0.0001185636],"genre_scores_gemma":[0.9967008,0.00004344659,0.002523705,0.00005512651,0.0004894265,0.000001771308,0.0000996536,0.000007154775,0.00007890113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00726747,"threshold_uncertainty_score":0.3613582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838554329061964,"score_gpt":0.2649679045701372,"score_spread":0.2365823612795176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}