{"id":"W2144367857","doi":"10.1074/jbc.m115.645051","title":"Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; U.S. Department of Veterans Affairs; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Pseudomonas aeruginosa; Guanosine monophosphate; Biology; Cystic fibrosis; Secretion; Mutant; Pathogen; Guanosine; Biochemistry; Microbiology; Chemistry; Gene; Bacteria; Nucleotide; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009864431,0.000251949,0.0002261752,0.0001050389,0.0001784458,0.0002707733,0.0002153162,0.0002152203,0.000596654],"category_scores_gemma":[0.0002263489,0.0001568884,0.0001487672,0.0001068423,0.0002202396,0.0001293137,0.0002581691,0.0004866669,0.0004521072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004506624,"about_ca_system_score_gemma":0.0002790725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265363,"about_ca_topic_score_gemma":0.001279841,"domain_scores_codex":[0.9998185,0.00003354562,0.00001163531,0.00002611203,0.0000812074,0.00002899051],"domain_scores_gemma":[0.999764,0.00003205601,0.0000787517,0.00002447278,0.00003090179,0.00006978344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001784103,0.00001163333,0.0001322908,0.000007045824,9.59057e-7,0.00002959982,0.000008401361,0.00002464127,0.999506,0.00001982829,0.00001536134,0.0002263105],"study_design_scores_gemma":[0.00001769259,0.000119662,0.01828585,0.000006546339,0.000007184332,0.0003548541,0.00007724924,0.002247189,0.9773279,0.00009026925,0.00145543,0.00001002302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979005,0.0003775229,0.0009608921,0.00009640707,0.00001009112,0.000009929292,0.00009788474,0.00005153935,0.0004951843],"genre_scores_gemma":[0.9980829,0.0001333883,0.0008969536,0.00004564751,0.000002957413,0.00001184095,0.0001940018,0.00001761569,0.0006147901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265363,"threshold_uncertainty_score":0.003269732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838554329061964,"score_gpt":0.2649679045701372,"score_spread":0.2365823612795176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}