{"id":"W2144385093","doi":"10.1093/hmg/ddi297","title":"HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS","year":2005,"lang":"de","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; University of Toronto; National Science Council; University of Pennsylvania","keywords":"SOD1; Mutant; Biology; Transgene; Genetically modified mouse; Amyotrophic lateral sclerosis; Cell biology; Homeobox; Molecular biology; Genetics; Gene; Gene expression; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003495945,0.0003754831,0.0006744683,0.0003167257,0.00007119902,0.00003901738,0.0003193719,0.0003415542,0.0003659033],"category_scores_gemma":[0.00002338688,0.0003770046,0.0001810886,0.0002823662,0.0003695282,0.00004108023,0.0001669826,0.0005064956,0.0000605872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334131,"about_ca_system_score_gemma":0.0001967238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005819138,"about_ca_topic_score_gemma":0.00004454849,"domain_scores_codex":[0.9967412,0.0001684162,0.0008708874,0.0006260806,0.0008239091,0.0007694711],"domain_scores_gemma":[0.9985635,0.00002305555,0.0001404388,0.0007656378,0.0001437939,0.0003635381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031152,0.0003448794,0.001643988,0.0002529408,0.0002624666,0.00004703581,0.002811,0.005052746,0.9831604,0.0001781774,0.0001475772,0.005995654],"study_design_scores_gemma":[0.01138453,0.001935568,0.06855239,0.0009908812,0.0009681879,0.00001224426,0.0001128956,0.3504043,0.5607949,0.002076317,0.001655271,0.001112487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683044,0.02843781,0.001091968,0.001098683,0.00005172243,0.0007149396,0.0000647669,0.00001390961,0.0002217841],"genre_scores_gemma":[0.9875853,0.009059467,0.002073292,0.000643111,0.0002238285,0.00001848341,0.0000271812,0.00009568742,0.0002736468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4223655,"threshold_uncertainty_score":0.9998682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04962086576409753,"score_gpt":0.3242141274674694,"score_spread":0.2745932617033718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}