{"id":"W2144399344","doi":"10.1186/1476-4598-9-145","title":"Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institutes of Health; Hospital for Sick Children; University of Toronto; U.S. Public Health Service; U.S. Department of Defense","keywords":"Biology; Catenin; Drug resistance; Cancer research; Signal transduction; Downregulation and upregulation; Beta-catenin; Cancer; GSK-3; Internal medicine; Cell biology; Pharmacology; Wnt signaling pathway; Genetics; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003477138,0.0001827952,0.0002013626,0.00004421432,0.00008611508,0.00003235033,0.0002316821,0.0001386751,0.00004276893],"category_scores_gemma":[0.00007533496,0.0001436176,0.00007490758,0.0001717271,0.0001265859,0.00001573048,0.00006861564,0.0001838754,3.545986e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001051928,"about_ca_system_score_gemma":0.00007761872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000416601,"about_ca_topic_score_gemma":0.0008293918,"domain_scores_codex":[0.9987499,0.0001106183,0.0002897101,0.0003860613,0.0002243105,0.0002394757],"domain_scores_gemma":[0.9993148,0.00002901877,0.000160375,0.0003658039,0.00008962207,0.00004041629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000948902,0.00002506738,0.002073025,0.00004706349,0.0000206505,0.000002704472,0.0007269203,0.000620977,0.9950112,0.0002012552,0.0002670244,0.0009092476],"study_design_scores_gemma":[0.0005573562,0.000007858911,0.006517908,0.0001196348,0.00002971501,0.000001941127,0.0001307815,0.0001099006,0.9835815,0.0005579341,0.008203979,0.0001815177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816962,0.01618844,0.001069327,0.0004252407,0.0002078148,0.0002362452,0.00001928592,0.000008141246,0.0001492793],"genre_scores_gemma":[0.9963964,0.0007035187,0.002064676,0.0003167487,0.0002077691,0.0001051106,0.0000263149,0.00002858981,0.0001508569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01548492,"threshold_uncertainty_score":0.5856557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006840323630350863,"score_gpt":0.2589368599747029,"score_spread":0.2520965363443521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}