{"id":"W2144417432","doi":"10.1002/prot.22854","title":"Molecular mechanism of β‐sheet self‐organization at water‐hydrophobic interfaces","year":2010,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Membrane; Hydrophobic effect; Biophysics; Lipid bilayer; Molecular dynamics; Self-assembly; Peptide; Conformational entropy; Beta sheet; Crystallography; Amphiphile; Molecule; Organic chemistry; Computational chemistry; Biochemistry; Copolymer; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004986761,0.0001430567,0.0001706263,0.0001092311,0.000107656,0.00002495346,0.0000425357,0.0001213526,0.0005231061],"category_scores_gemma":[0.00002168051,0.00008794377,0.00003274201,0.000130637,0.00005507146,0.0001338454,0.00007497322,0.0001554767,0.00003270527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002658231,"about_ca_system_score_gemma":0.00004472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008579766,"about_ca_topic_score_gemma":0.000005890771,"domain_scores_codex":[0.9992026,0.00001131888,0.0002322863,0.0001080848,0.0002685611,0.000177162],"domain_scores_gemma":[0.9993858,0.000004997165,0.00007983613,0.000191645,0.0001748213,0.0001629509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004039127,0.0002082487,0.005258082,0.001036074,0.002264793,0.00001288067,0.001226504,0.00000562078,0.984482,0.001740948,0.00009518941,0.003265707],"study_design_scores_gemma":[0.001467968,0.0006079837,0.00232121,0.00003181965,0.0003312216,0.0001022335,0.00009979925,0.002207124,0.9915665,0.001006689,0.0001317308,0.0001257279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973543,0.00009774961,0.001191273,0.0001205328,0.000134998,0.0006646993,0.00002949118,0.00006888221,0.0003380373],"genre_scores_gemma":[0.9952537,0.00002596772,0.004357899,0.00008115047,0.00002959403,0.000007711132,0.0002063636,0.0000146792,0.00002295202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007084453,"threshold_uncertainty_score":0.5727646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005138525802805784,"score_gpt":0.2190636118555085,"score_spread":0.2139250860527028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}