{"id":"W2144423516","doi":"10.1261/rna.047985.114","title":"The low information content of <i>Neurospora</i> splicing signals: implications for RNA splicing and intron origin","year":2015,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canada Research Chairs; Alfred P. Sloan Foundation","keywords":"Intron; Biology; RNA splicing; Genetics; Spliceosome; Gene; Group II intron; Splice site mutation; Splicing factor; splice; Exonic splicing enhancer; Genome; Group I catalytic intron; Computational biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002887859,0.00007414992,0.00008687823,0.00001653279,0.00008858653,0.00002973688,0.0001046406,0.00005300389,5.417663e-7],"category_scores_gemma":[0.0001398305,0.00005465246,0.0000362639,0.000034032,0.00003148181,0.00001023944,0.00003637566,0.00002760595,0.000001502014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007879191,"about_ca_system_score_gemma":0.00003842996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002828222,"about_ca_topic_score_gemma":0.000005800219,"domain_scores_codex":[0.9995039,0.00002161635,0.0001985801,0.00009640783,0.00005856525,0.0001209113],"domain_scores_gemma":[0.9994522,0.00002968846,0.000139373,0.0001954659,0.0001299502,0.00005334337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005806292,0.000006424712,0.000144027,0.00001630721,0.00001111539,2.27266e-8,0.00004850068,0.00002528395,0.9705276,0.001693,0.0004369971,0.02703264],"study_design_scores_gemma":[0.0002871967,0.0001782553,0.0003998401,0.00001743394,0.00001285586,0.000003269744,0.0001416764,0.0001086008,0.982334,0.0009508734,0.01549082,0.00007518703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564009,0.0004067178,0.04160327,0.0007022332,0.000094235,0.0004315752,0.00002362829,0.000007647294,0.0003297662],"genre_scores_gemma":[0.9985732,0.0001478555,0.0007940418,0.000215308,0.00008022303,0.00005614479,0.0000240031,0.000007955076,0.0001012513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04217229,"threshold_uncertainty_score":0.2228663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770143007212482,"score_gpt":0.2677150581530632,"score_spread":0.2300136280809384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}