{"id":"W2144423516","doi":"10.1261/rna.047985.114","title":"The low information content of <i>Neurospora</i> splicing signals: implications for RNA splicing and intron origin","year":2015,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canada Research Chairs; Alfred P. Sloan Foundation","keywords":"Intron; Biology; RNA splicing; Genetics; Spliceosome; Gene; Group II intron; Splice site mutation; Splicing factor; splice; Exonic splicing enhancer; Genome; Group I catalytic intron; Computational biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003874107,0.0002662833,0.0004276993,0.000679681,0.0003006717,0.0008838528,0.0003818425,0.0003523815,0.001137513],"category_scores_gemma":[0.001407279,0.0002062755,0.0002576588,0.0004640245,0.0004942142,0.0005221409,0.0002220934,0.0004482641,0.0004730325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004587494,"about_ca_system_score_gemma":0.0003704574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007368768,"about_ca_topic_score_gemma":0.0007646107,"domain_scores_codex":[0.9996197,0.00005727132,0.00003575726,0.0001160527,0.0001113579,0.00005986011],"domain_scores_gemma":[0.9988565,0.000534115,0.0002071531,0.0001664217,0.0001353449,0.0001004031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001963593,0.00001903414,0.005265828,0.0001265105,0.00002271775,0.0002347807,0.00005264614,0.0004029368,0.983014,0.001014098,0.0001121717,0.00953878],"study_design_scores_gemma":[0.00001934834,0.000149965,0.05012924,0.00004326725,0.00007709515,0.001433277,0.00008855692,0.004938772,0.9358402,0.003979836,0.00327284,0.00002763385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742857,0.001175817,0.02084531,0.0003799875,0.0000261217,0.00001609753,0.001088752,0.0002189823,0.001963145],"genre_scores_gemma":[0.9919649,0.0003367295,0.005937822,0.0001068535,0.00001300795,0.00001566286,0.001191643,0.00004597653,0.0003873955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137513,"threshold_uncertainty_score":0.003805399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770143007212482,"score_gpt":0.2677150581530632,"score_spread":0.2300136280809384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}