{"id":"W2144441934","doi":"10.1128/aem.70.8.4569-4574.2004","title":"Expression and Immunogenicity of a Recombinant Diphtheria Toxin Fragment A in <i>Streptococcus gordonii</i>","year":2004,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; IWK Health Centre","keywords":"Streptococcus gordonii; Diphtheria toxin; Immunogenicity; Microbiology; Corynebacterium diphtheriae; Recombinant DNA; Biology; Molecular biology; Antibody; Antiserum; Cholera toxin; Virology; Toxin; Diphtheria; Streptococcaceae; Immunology; Biochemistry; Gene; Vaccination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141461,0.0002319785,0.000386354,0.00006855978,0.00009581213,0.000005035038,0.0001239777,0.0003022852,0.0001940964],"category_scores_gemma":[0.000002864082,0.0002002264,0.00004722851,0.00004213518,0.0004230221,0.00003809035,0.00026004,0.0002238291,0.00003352958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006225597,"about_ca_system_score_gemma":0.00001320644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108757,"about_ca_topic_score_gemma":0.00001468364,"domain_scores_codex":[0.9988028,0.00005701733,0.0003797635,0.0004066942,0.00001348663,0.0003402449],"domain_scores_gemma":[0.9995977,0.00003243829,0.000129561,0.0002158001,0.000001659876,0.00002279564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001615254,0.0003117599,0.001409422,0.00001325151,0.00003751482,0.000002553966,0.0005165456,0.000004729233,0.9943072,0.0005484719,0.00001367442,0.002673346],"study_design_scores_gemma":[0.00449163,0.0003421125,0.0114815,0.00004534479,0.00001573869,0.00008242832,0.0007916217,2.043173e-7,0.9783295,0.0009824084,0.003203602,0.0002339308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956738,0.00338571,0.00006165124,0.00004733207,0.0001968944,0.0004277328,0.00005985572,0.00001498158,0.0001320798],"genre_scores_gemma":[0.99834,0.000932216,0.0003159981,0.0001129221,0.000005056518,0.00006120095,0.0001302359,0.00001668373,0.00008564915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01597773,"threshold_uncertainty_score":0.8164996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003892589649024017,"score_gpt":0.1740308530569449,"score_spread":0.1701382634079209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}