{"id":"W2144441934","doi":"10.1128/aem.70.8.4569-4574.2004","title":"Expression and Immunogenicity of a Recombinant Diphtheria Toxin Fragment A in <i>Streptococcus gordonii</i>","year":2004,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; IWK Health Centre","keywords":"Streptococcus gordonii; Diphtheria toxin; Immunogenicity; Microbiology; Corynebacterium diphtheriae; Recombinant DNA; Biology; Molecular biology; Antibody; Antiserum; Cholera toxin; Virology; Toxin; Diphtheria; Streptococcaceae; Immunology; Biochemistry; Gene; Vaccination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493652,0.0003313484,0.0001467945,0.0001345785,0.0001078189,0.0002284474,0.000140041,0.0002666481,0.0004592567],"category_scores_gemma":[0.0001433539,0.000105901,0.0002126893,0.0001243135,0.0001976765,0.0001100787,0.0001503501,0.0003910351,0.0002144242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004805205,"about_ca_system_score_gemma":0.0001759657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001801182,"about_ca_topic_score_gemma":0.001373751,"domain_scores_codex":[0.9998686,0.00002303716,0.00001330243,0.00001889588,0.00004097265,0.00003505279],"domain_scores_gemma":[0.9998695,0.00002146478,0.00003194491,0.00001870115,0.0000238297,0.00003453314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000290165,0.00001000208,0.00009387155,0.000005327607,0.000001170391,0.00001404039,0.000003823709,0.00001310837,0.9997333,0.00001232975,0.000004120728,0.00008003801],"study_design_scores_gemma":[0.00001642361,0.0008206918,0.008671892,0.000005266509,0.00002183746,0.0002888358,0.00003995066,0.0006847038,0.9886264,0.00002712245,0.0007939923,0.00000296927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992661,0.0001353939,0.0002970195,0.00002209394,0.000005949771,0.000004588585,0.00005645373,0.000007110994,0.0002053746],"genre_scores_gemma":[0.9982526,0.0001196939,0.0005129703,0.00002044034,0.000003298179,0.000004947685,0.0003943363,0.000007153246,0.0006846208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001801182,"threshold_uncertainty_score":0.003581405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003892589649024017,"score_gpt":0.1740308530569449,"score_spread":0.1701382634079209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}