{"id":"W2144445863","doi":"10.1158/1078-0432.ccr-10-3266","title":"Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Oncolytics Biotech; U.S. Public Health Service; Cancer Research UK; National Cancer Institute; Richard M. Schulze Family Foundation","keywords":"Oncolytic virus; Virology; Virus; Immune system; Neutralizing antibody; Internalization; Biology; Cell culture; Cell; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00197355,0.0001363352,0.0002075552,0.00006918469,0.0001945522,0.00003126283,0.0007722017,0.0002388027,0.0004551361],"category_scores_gemma":[0.0003334048,0.000108447,0.0001265494,0.000302346,0.0007003815,0.000008006038,0.0002296782,0.0005149271,0.00002211421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006764005,"about_ca_system_score_gemma":0.0003927129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003947209,"about_ca_topic_score_gemma":0.003174407,"domain_scores_codex":[0.9967499,0.001234152,0.0005276689,0.0004951685,0.00057154,0.0004215772],"domain_scores_gemma":[0.9984033,0.0001280799,0.000135253,0.0006965476,0.0004608394,0.0001760213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002528578,0.0002689412,0.007211668,0.00004078377,0.00008917742,0.000003855533,0.000265867,0.00001672729,0.9800404,0.00003469899,0.005395093,0.004104226],"study_design_scores_gemma":[0.0009627414,0.003177121,0.001464296,0.00004074063,0.00001556227,3.695048e-7,0.00009234024,0.00006821735,0.9871405,0.0005972899,0.006305382,0.0001353944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99496,0.002150864,0.0006585043,0.00009475624,0.0001361246,0.0007687563,0.00009169707,0.00001013843,0.00112921],"genre_scores_gemma":[0.9969789,0.001427137,0.0000335806,0.0001953704,0.0002997202,0.0002170058,0.00007797532,0.00004361423,0.0007267149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007100162,"threshold_uncertainty_score":0.5967025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1767075116194609,"score_gpt":0.4727083875083239,"score_spread":0.296000875888863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}