{"id":"W2144445863","doi":"10.1158/1078-0432.ccr-10-3266","title":"Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Oncolytics Biotech; U.S. Public Health Service; Cancer Research UK; National Cancer Institute; Richard M. Schulze Family Foundation","keywords":"Oncolytic virus; Virology; Virus; Immune system; Neutralizing antibody; Internalization; Biology; Cell culture; Cell; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162402,0.0003672963,0.0002461854,0.0001476694,0.0001110319,0.0003772984,0.0001742477,0.0003585932,0.0007692988],"category_scores_gemma":[0.000202163,0.00009946997,0.0002608469,0.00007265958,0.0002236227,0.0002440487,0.0001609911,0.0003829676,0.0003910383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083601,"about_ca_system_score_gemma":0.0003542322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007084554,"about_ca_topic_score_gemma":0.0004687188,"domain_scores_codex":[0.9998553,0.00002156276,0.000009438001,0.00003429586,0.00003791357,0.00004148703],"domain_scores_gemma":[0.9999112,0.00002064468,0.00001966253,0.00002199741,0.0000157874,0.00001078651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009444309,0.00002330708,0.0001102395,0.00002574441,0.000003040977,0.00003785649,0.00001417628,0.0001204631,0.9978006,0.0001034599,0.00002881846,0.001637749],"study_design_scores_gemma":[0.00001748772,0.0003168419,0.0004527382,0.000007601649,0.00000926342,0.0001685888,0.000009152643,0.001185251,0.9962175,0.00003016579,0.001582815,0.000002638463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891278,0.0018608,0.007167134,0.00007172672,0.00003366945,0.00006245945,0.00009464758,0.000104989,0.001476731],"genre_scores_gemma":[0.9948891,0.0006118955,0.002622785,0.00003460692,0.000009636528,0.00001875387,0.000186783,0.00002117744,0.001605311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007692988,"threshold_uncertainty_score":0.002962947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1767075116194609,"score_gpt":0.4727083875083239,"score_spread":0.296000875888863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}