{"id":"W2144451670","doi":"10.1084/jem.20062041","title":"Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell–like diffuse large B cell lymphoma","year":2007,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"BCL6; Immunoglobulin class switching; Diffuse large B-cell lymphoma; Germinal center; Cytidine deaminase; Biology; Somatic hypermutation; Chromosomal translocation; B cell; Lymphoma; Immunoglobulin heavy chain; Cancer research; Molecular biology; Genetics; Antibody; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050239,0.000226163,0.0004736516,0.0002519684,0.0001200255,0.000009255392,0.0001299945,0.00009470527,0.0001091665],"category_scores_gemma":[0.00002908544,0.000132126,0.00007719905,0.0003178751,0.0001118392,0.0001281726,0.00002672574,0.0001834903,0.000006151185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004806929,"about_ca_system_score_gemma":0.0000897194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002451809,"about_ca_topic_score_gemma":0.00002883562,"domain_scores_codex":[0.9982039,0.00009103359,0.0007703739,0.0001520829,0.0004696504,0.0003129091],"domain_scores_gemma":[0.9988388,0.0002801879,0.0003350269,0.0002278977,0.0001110078,0.0002070698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002545236,0.01478832,0.007850515,0.00004631176,0.0001288399,0.0002763691,0.01326819,0.000001322847,0.9546686,0.00007997445,0.001245872,0.005100393],"study_design_scores_gemma":[0.06798699,0.003029872,0.1130435,0.0005161864,0.0002958441,0.0007851116,0.01468876,0.00006866449,0.7975693,0.00005044682,0.001796816,0.0001685168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811901,0.01282901,0.00009583701,0.003391537,0.0003545357,0.0004157498,0.000002241872,0.00001214154,0.001708789],"genre_scores_gemma":[0.9974303,0.001440363,0.0001355876,0.0006213993,0.000140419,0.00001196338,0.00001148822,0.00002415049,0.0001842794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1570993,"threshold_uncertainty_score":0.5387943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313066179906773,"score_gpt":0.2822725726073946,"score_spread":0.2691419108083269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}