{"id":"W2144463818","doi":"10.1002/jgm.1598","title":"Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb","year":2011,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Immunogenicity; Receptor; Antibody; Fragment crystallizable region; Mutant; Fc receptor; Immunoglobulin Fc Fragments; Chemistry; Molecular biology; DNA vaccination; Naked DNA; Immunoglobulin G; Recombinant DNA; Biology; Gene; Immunology; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002044644,0.0002870231,0.0005966365,0.0001635572,0.0003109992,0.000009752289,0.0004789128,0.0001102789,0.0009988303],"category_scores_gemma":[0.0001223477,0.0001405899,0.0001722235,0.0004491351,0.0004149194,0.000117469,0.00002137382,0.000750838,0.0000706648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113176,"about_ca_system_score_gemma":0.0002631309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729737,"about_ca_topic_score_gemma":0.000005335977,"domain_scores_codex":[0.9972612,0.0006286497,0.0009119494,0.0001539244,0.0006930662,0.0003512533],"domain_scores_gemma":[0.9984147,0.0002285482,0.0002590733,0.0005209633,0.0003615374,0.0002151628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006610964,0.0001054639,0.00005038713,0.00002898429,0.0004234863,0.00002693203,0.03783537,0.000001758756,0.9405265,0.000007993202,0.006734297,0.007647864],"study_design_scores_gemma":[0.005501322,0.003001589,0.001370034,0.0006008476,0.0007630292,0.001385512,0.006587649,0.0000105957,0.9632413,0.00002748405,0.01731233,0.0001982548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735586,0.008468722,0.003090628,0.01264686,0.0006342949,0.0007557956,0.00003779413,0.00002466632,0.0007826412],"genre_scores_gemma":[0.9833926,0.005967543,0.00083585,0.008634412,0.0004788239,0.000008257533,0.00001998061,0.00004833434,0.0006141811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03124773,"threshold_uncertainty_score":0.9999144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04624541195141574,"score_gpt":0.2799277792190998,"score_spread":0.2336823672676841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}