{"id":"W2144463818","doi":"10.1002/jgm.1598","title":"Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb","year":2011,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Immunogenicity; Receptor; Antibody; Fragment crystallizable region; Mutant; Fc receptor; Immunoglobulin Fc Fragments; Chemistry; Molecular biology; DNA vaccination; Naked DNA; Immunoglobulin G; Recombinant DNA; Biology; Gene; Immunology; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002579176,0.0007295864,0.0002995164,0.0003456123,0.0001054708,0.0002695413,0.0003217766,0.0004544654,0.002173182],"category_scores_gemma":[0.0002010427,0.0001543816,0.0003265864,0.0001363281,0.0004231236,0.0002483818,0.0002551149,0.001028624,0.0004453112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000352873,"about_ca_system_score_gemma":0.0001421005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001377797,"about_ca_topic_score_gemma":0.0001050332,"domain_scores_codex":[0.9996698,0.00005616865,0.00002667081,0.00007014329,0.00009290615,0.00008421699],"domain_scores_gemma":[0.9997719,0.00005914262,0.00009380707,0.00002602912,0.00001618555,0.00003288676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118275,0.00004232952,0.00008868278,0.00002494319,0.000004987229,0.00002265286,0.000005343321,0.00004271456,0.998995,0.00005416869,0.00002157863,0.0005857655],"study_design_scores_gemma":[0.0000202396,0.0005089605,0.0007701765,0.000004182506,0.00001626625,0.0001712208,0.000006309195,0.0004018671,0.9973977,0.00001788,0.0006836491,0.000001617433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934037,0.0005139976,0.004870817,0.00007939827,0.00002367054,0.00003055336,0.0001217664,0.0001173661,0.0008386276],"genre_scores_gemma":[0.9954849,0.0002876531,0.002340059,0.00004804466,0.00001780634,0.00004884474,0.0003229344,0.00002668916,0.001423092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002173182,"threshold_uncertainty_score":0.007270038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04624541195141574,"score_gpt":0.2799277792190998,"score_spread":0.2336823672676841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}