{"id":"W2144473770","doi":"10.1093/hmg/ddp299","title":"Inactive X chromosome-specific reduction in placental DNA methylation","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Methylation; CpG site; Biology; DNA methylation; Promoter; Placenta; Intergenic region; Molecular biology; X-inactivation; Andrology; Genetics; Gene; X chromosome; Genome; Gene expression; Fetus; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380183,0.0002452301,0.0002586421,0.0004768644,0.0001253353,0.000325193,0.0002196883,0.0001968458,0.005182633],"category_scores_gemma":[0.0005992274,0.0001936185,0.0001902447,0.000240793,0.0002835493,0.0001271002,0.0003278736,0.0005247139,0.0005563778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793129,"about_ca_system_score_gemma":0.0001446071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055822,"about_ca_topic_score_gemma":0.0006229571,"domain_scores_codex":[0.9997534,0.00004321723,0.00001174045,0.00009729221,0.00006370922,0.00003045948],"domain_scores_gemma":[0.9996684,0.00007828114,0.00009769011,0.00005488417,0.00004044803,0.00006042559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002815418,0.00001500121,0.009662541,0.00005436995,0.00003159839,0.0002671033,0.0001246323,0.00007119687,0.9825179,0.0001850617,0.0001389079,0.006650042],"study_design_scores_gemma":[0.00002830562,0.0006454013,0.4960104,0.00002019896,0.0000641385,0.003443941,0.0001813879,0.0006151571,0.4920326,0.000402907,0.006539284,0.0000162601],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840018,0.003058473,0.005674983,0.0001573394,0.0000334088,0.00003233019,0.001639189,0.0002099125,0.005192613],"genre_scores_gemma":[0.9908823,0.001023751,0.001066621,0.00007856881,0.00001324715,0.00002954668,0.001294771,0.00005042517,0.005560794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005182633,"threshold_uncertainty_score":0.01733762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489718146457746,"score_gpt":0.2766389256808927,"score_spread":0.2617417442163152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}