{"id":"W2144474352","doi":"10.1128/jb.183.20.5885-5895.2001","title":"In Vivo Synthesis of the Periplasmic Domain of TonB Inhibits Transport through the FecA and FhuA Iron Siderophore Transporters of <i>Escherichia coli</i>","year":2001,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Periplasmic space; Ferrichrome; Colicin; Bacterial outer membrane; Biology; Siderophore; Escherichia coli; Chemiosmosis; Cytoplasm; Enterobactin; Transport protein; Membrane transport protein; Biochemistry; Signal peptide; Permease; Membrane protein; Biophysics; Peptide sequence; Membrane; Gene; ATP synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944859,0.0003862215,0.0002136807,0.00009711114,0.0001269996,0.0003293467,0.0002454617,0.0002592391,0.001139835],"category_scores_gemma":[0.0001957523,0.0001876406,0.0002232631,0.00008942034,0.0002634191,0.000118312,0.0001796352,0.0005248054,0.00038978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004411873,"about_ca_system_score_gemma":0.0002436407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009344118,"about_ca_topic_score_gemma":0.001022116,"domain_scores_codex":[0.9998428,0.00003458113,0.00001760436,0.00002366386,0.00004336845,0.00003797961],"domain_scores_gemma":[0.9997583,0.00008016567,0.00006119681,0.00002703666,0.00001414502,0.00005913786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009095256,0.00004125694,0.00008504879,0.0000133505,0.000003289706,0.00001864143,0.000008663494,0.00005207543,0.9994133,0.00005665882,0.00001144559,0.00020538],"study_design_scores_gemma":[0.00002284249,0.0002955394,0.001663304,0.000004836716,0.000008897127,0.0001228577,0.00001749997,0.0008920896,0.9959918,0.0000226727,0.0009541442,0.000003532454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980518,0.0003156294,0.0009254165,0.00005464346,0.00001584339,0.00001283376,0.0001421206,0.0000304367,0.0004513078],"genre_scores_gemma":[0.9963031,0.0001620843,0.001404842,0.00003615466,0.000006653389,0.00001887097,0.000683234,0.00003138285,0.00135368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139835,"threshold_uncertainty_score":0.003813148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005603655317028888,"score_gpt":0.2045785031640717,"score_spread":0.1989748478470428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}