{"id":"W2144502394","doi":"10.1158/0008-5472.can-05-2598","title":"Low-Dose Metronomic Daily Cyclophosphamide and Weekly Tirapazamine: A Well-Tolerated Combination Regimen with Enhanced Efficacy That Exploits Tumor Hypoxia","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Tirapazamine; Cyclophosphamide; Medicine; Hypoxia (environmental); Chemotherapy; Tumor hypoxia; Pharmacology; Cancer; Cancer research; Oncology; Internal medicine; Cytotoxicity; Radiation therapy; Biology; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004442382,0.000266037,0.000302653,0.0001745395,0.0002299717,0.0001119068,0.0002849615,0.000130006,0.00005926819],"category_scores_gemma":[0.00004426183,0.0002425323,0.0000605183,0.0003925218,0.0003303407,0.00002301598,0.0001482905,0.00028469,0.00002241768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103223,"about_ca_system_score_gemma":0.0004111455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008672577,"about_ca_topic_score_gemma":0.0004540788,"domain_scores_codex":[0.9977574,0.0001616269,0.0002402705,0.0007475347,0.0004249108,0.0006682999],"domain_scores_gemma":[0.9988574,0.00004759418,0.0001082697,0.0004975061,0.0003064871,0.000182695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001056388,0.0001928793,0.0005002579,0.00005572308,0.00007502594,0.000005441933,0.00008679905,0.0001147636,0.9794019,0.00009178033,0.0123949,0.006024164],"study_design_scores_gemma":[0.004915035,0.000444753,0.03258453,0.00008660459,0.00003111411,0.00001121503,0.0002126972,0.00003695619,0.8996256,0.00006044072,0.06160796,0.0003830858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878102,0.008901041,0.0001566025,0.0002878297,0.0003153118,0.0006971128,0.00002709807,0.00003037409,0.00177441],"genre_scores_gemma":[0.9891901,0.002471744,0.0001337648,0.0001027398,0.0008367758,0.0003486478,0.0001492838,0.00006783628,0.006699088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07977627,"threshold_uncertainty_score":0.989018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844842676887849,"score_gpt":0.2936771452451152,"score_spread":0.2752287184762367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}