{"id":"W2144541396","doi":"10.18433/j3x60d","title":"Development of Lyophilized Gemini Surfactant-Based Gene Delivery Systems: Influence of Lyophilization on the Structure, Activity and Stability of the Lipoplexes","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Trehalose; Transfection; Pulmonary surfactant; Chemistry; Gene delivery; Freeze-drying; In vitro; Chromatography; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001354082,0.000125586,0.0002192291,0.00004698203,0.0001102038,0.00001292065,0.0004259743,0.000042533,0.00002420635],"category_scores_gemma":[0.0002126878,0.00006691388,0.00009067956,0.0002015704,0.0005930043,0.0000365407,0.0001097254,0.0001307192,1.605171e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002035255,"about_ca_system_score_gemma":0.0003325739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001797125,"about_ca_topic_score_gemma":0.000004480057,"domain_scores_codex":[0.9984089,0.000248222,0.0005221302,0.00013668,0.0004809954,0.0002031069],"domain_scores_gemma":[0.9987178,0.0001515434,0.0005855192,0.0001406619,0.000307075,0.00009742754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003468276,0.000129315,0.04572462,0.00006880216,0.00004671557,1.487635e-7,0.0001648514,0.0007932305,0.95059,0.00001803389,0.00001027616,0.002107209],"study_design_scores_gemma":[0.000443122,0.0001209949,0.02643488,0.00005593467,0.00004777415,0.000007892157,0.0001102225,0.0006491656,0.9715616,0.000007011445,0.0004903697,0.00007110508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980556,0.001360515,0.00006687062,0.0001119618,0.0001935051,0.000166268,0.00002628606,0.000001091079,0.00001791755],"genre_scores_gemma":[0.9992987,0.0002937735,0.0002444149,0.00009648262,0.00005960045,0.000001229494,6.425286e-7,0.000003982836,0.000001171211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02097156,"threshold_uncertainty_score":0.2728669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05959312348720439,"score_gpt":0.3368054702759671,"score_spread":0.2772123467887627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}