{"id":"W2144561973","doi":"10.1534/genetics.110.118109","title":"<i>Y</i>Not a Dead End: Epistatic Interactions Between<i>Y-</i>Linked Regulatory Polymorphisms and Genetic Background Affect Global Gene Expression in<i>Drosophila melanogaster</i>","year":2010,"lang":"en","type":"article","venue":"Genetics","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Genetics; Autosome; Gene; Y chromosome; Drosophila melanogaster; Epistasis; Heterochromatin; X chromosome; Dosage compensation; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001549856,0.0003426248,0.0003268666,0.000113988,0.0001471084,0.00008390347,0.0003033771,0.0002985652,0.00007858667],"category_scores_gemma":[0.00004414665,0.0003401465,0.0001231236,0.0002031499,0.0003283395,0.00001194915,0.0002650683,0.0002885116,0.00002326452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001733768,"about_ca_system_score_gemma":0.00008355255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002099111,"about_ca_topic_score_gemma":0.000467537,"domain_scores_codex":[0.9979569,0.0001124485,0.0005783167,0.0006323131,0.0002708355,0.0004491534],"domain_scores_gemma":[0.9988461,0.00006439859,0.0001765538,0.0005531975,0.00007831092,0.0002815149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006454951,0.0001111391,0.05303418,0.00003470736,0.00003376091,0.00002581816,0.00006366899,0.00002246623,0.9400664,0.00008064281,0.0002831326,0.006179535],"study_design_scores_gemma":[0.00145932,0.0004680303,0.6094511,0.00004375627,0.0000649624,0.0002333046,0.000149295,0.00005283316,0.3778982,0.0008367149,0.008799966,0.000542486],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971548,0.0005951162,0.0003927859,0.0003745952,0.0004170261,0.0002637043,0.0001069752,0.00002567121,0.0006693671],"genre_scores_gemma":[0.9869188,0.0004383948,0.01091218,0.0005928887,0.0005679023,0.00003705606,0.0001211537,0.0000358106,0.0003757809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5621682,"threshold_uncertainty_score":0.999905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646591833532942,"score_gpt":0.2780860890561416,"score_spread":0.2616201707208122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}