{"id":"W2144578935","doi":"10.1016/j.cell.2011.08.050","title":"Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":576,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Transcription factor; Transforming growth factor; Transcription (linguistics); Embryonic stem cell; Cell biology; Cell type; Transforming growth factor beta; Genetics; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660843,0.0001706085,0.000123064,0.00009428262,0.00006808792,0.00002562483,0.0002682042,0.0001371405,0.0003643668],"category_scores_gemma":[0.0000129239,0.0001580947,0.00008727513,0.0001104652,0.00003864087,0.000005088053,0.00007673738,0.00009918951,0.0002685186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001680556,"about_ca_system_score_gemma":0.00003536124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001199534,"about_ca_topic_score_gemma":0.000004707393,"domain_scores_codex":[0.9987852,0.00009706011,0.0001926619,0.0003998026,0.0001714998,0.0003538],"domain_scores_gemma":[0.9993179,0.00001429228,0.00003754857,0.0003744992,0.00008170642,0.0001740919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004123466,0.00007735199,0.001356447,0.00002740848,0.000006225159,0.00001314386,0.0003513297,0.000008210004,0.9958635,6.643701e-7,0.001701763,0.0001816301],"study_design_scores_gemma":[0.0002962946,0.0004184936,0.001762844,0.000007605015,0.000006835157,0.000002604197,0.000142138,0.000007134032,0.9414761,0.000005365792,0.05568701,0.0001875697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911017,0.0004983868,0.001292223,0.00001880408,0.0002876516,0.0002359816,0.00001377379,0.00001668728,0.006534752],"genre_scores_gemma":[0.9842538,0.0001102377,0.000944827,0.00008104038,0.0001282229,0.000009342622,0.00005274537,0.00003575636,0.014384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05438737,"threshold_uncertainty_score":0.6446915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06964327126296888,"score_gpt":0.2580272797030587,"score_spread":0.1883840084400898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}