{"id":"W2144578935","doi":"10.1016/j.cell.2011.08.050","title":"Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":576,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Transcription factor; Transforming growth factor; Transcription (linguistics); Embryonic stem cell; Cell biology; Cell type; Transforming growth factor beta; Genetics; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003629212,0.0003616792,0.0003584283,0.0004266032,0.0002186284,0.0008058575,0.0002767866,0.0003095354,0.002039976],"category_scores_gemma":[0.0003841758,0.0005024107,0.0003048696,0.0002192323,0.0003442253,0.0007054267,0.0005158507,0.001018479,0.0006484783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005297862,"about_ca_system_score_gemma":0.0002778264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003783406,"about_ca_topic_score_gemma":0.0009297308,"domain_scores_codex":[0.9997082,0.00003400836,0.0000278254,0.00008624813,0.00006040155,0.00008334763],"domain_scores_gemma":[0.9997098,0.00006962034,0.00006932794,0.00003129836,0.00004151986,0.00007846092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009605147,0.000005074164,0.0005889916,0.00001489317,0.000002950743,0.00002327143,0.00003508557,0.00002701276,0.9976894,0.0004915011,0.00003496265,0.000990827],"study_design_scores_gemma":[0.00002101836,0.0000814542,0.02794893,0.00001713591,0.0000279982,0.0002033414,0.0001788381,0.001109141,0.9667284,0.0005231344,0.003150058,0.00001049595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838831,0.003473411,0.006535342,0.0002142523,0.0000919032,0.00003724865,0.0009045324,0.0001035513,0.004756515],"genre_scores_gemma":[0.9912883,0.001295199,0.00185973,0.0001090712,0.00004013455,0.00003481488,0.000780112,0.00008032045,0.00451223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039976,"threshold_uncertainty_score":0.006824374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06964327126296888,"score_gpt":0.2580272797030587,"score_spread":0.1883840084400898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}