{"id":"W2144650266","doi":"10.2337/diabetes.53.8.2003","title":"Hyperresponsiveness, Resistance to B-Cell Receptor—Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes","year":2004,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"Canadian Diabetes Association","keywords":"Insulitis; NOD mice; Nod; Biology; Congenic; Endocrinology; Immunology; Internal medicine; B cell; Medicine; Antibody; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471427,0.0001969704,0.0002866995,0.00008667389,0.00006546725,0.0000215167,0.0001653117,0.0001724001,0.000008261247],"category_scores_gemma":[0.0002954495,0.0001643407,0.00004737194,0.0003514806,0.0000550021,0.00001832514,0.00006458229,0.0001120505,0.000002442737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004420858,"about_ca_system_score_gemma":0.0001232486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006352307,"about_ca_topic_score_gemma":0.00003947974,"domain_scores_codex":[0.9987647,0.00012453,0.0002703732,0.0003257366,0.0002150746,0.0002996189],"domain_scores_gemma":[0.998969,0.0001920743,0.0002689665,0.0002527597,0.0002614073,0.00005582709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001291419,0.0002543556,0.03094567,0.00003260257,0.00006601608,3.317861e-7,0.0002030901,0.000335039,0.9677408,0.000004511935,0.0001320958,0.0001562948],"study_design_scores_gemma":[0.001453549,0.0003140019,0.03724703,0.0001220327,0.00002538326,2.471632e-8,0.0002105245,0.00001159217,0.9601663,0.00003402726,0.000217926,0.0001976495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986775,0.0002422988,0.000002904465,0.0003900501,0.0000491914,0.0003309851,0.0001699806,0.000008121044,0.0001289535],"genre_scores_gemma":[0.9990656,0.00006318583,0.00009782488,0.000409081,0.00001290048,0.00002489474,0.0001420547,0.00002907444,0.000155394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007574591,"threshold_uncertainty_score":0.6701621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382884558867166,"score_gpt":0.2383809360717002,"score_spread":0.2245520904830285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}