{"id":"W2144650266","doi":"10.2337/diabetes.53.8.2003","title":"Hyperresponsiveness, Resistance to B-Cell Receptor—Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes","year":2004,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"Canadian Diabetes Association","keywords":"Insulitis; NOD mice; Nod; Biology; Congenic; Endocrinology; Immunology; Internal medicine; B cell; Medicine; Antibody; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451124,0.0004082427,0.0002731096,0.0005451688,0.0001276874,0.0003439111,0.0001349697,0.0003062939,0.001435574],"category_scores_gemma":[0.0001858323,0.0002286196,0.0002328151,0.0001528418,0.0002328384,0.000191662,0.0002492123,0.0007125186,0.0003041246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140684,"about_ca_system_score_gemma":0.00006549779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001446942,"about_ca_topic_score_gemma":0.0001749112,"domain_scores_codex":[0.9997492,0.00003399464,0.00003159928,0.000064122,0.00006351423,0.00005758464],"domain_scores_gemma":[0.9996536,0.00004257089,0.0001324614,0.00004577559,0.00001961112,0.0001059225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008147863,0.000009917215,0.0008345655,0.00001124931,0.000002635299,0.00005611636,0.00001047681,0.000009815652,0.9986753,0.00001260714,0.000007593568,0.0002882922],"study_design_scores_gemma":[0.00004326721,0.000811054,0.1399327,0.00001528399,0.00004258642,0.006028992,0.00009409706,0.0004332281,0.8508489,0.00008441968,0.001649869,0.00001557229],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979673,0.00086651,0.0004466091,0.00002227641,0.000008358657,0.000009094712,0.0001560683,0.00004011949,0.0004836568],"genre_scores_gemma":[0.9975507,0.0004819482,0.0005637345,0.00003893576,0.00001286997,0.00002245896,0.0004471154,0.00001664393,0.0008657117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435574,"threshold_uncertainty_score":0.004802465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382884558867166,"score_gpt":0.2383809360717002,"score_spread":0.2245520904830285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}