{"id":"W2144661178","doi":"10.1136/jmg.2004.027698","title":"Melanocortin-1 receptor gene variants affect pain and μ-opioid analgesia in mice and humans","year":2005,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Canada Research Chairs; Children's Miracle Network Hospitals","keywords":"Opioid; μ-opioid receptor; Morphine; Melanocortin; Melanocortin 1 receptor; Analgesic; Opioid receptor; Pharmacogenetics; Pharmacology; Medicine; Receptor; Nociception; Genotype; Internal medicine; Biology; Endocrinology; Allele; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001689384,0.00009549718,0.0002057174,0.0001182718,0.000052796,0.00003699066,0.0001935021,0.0001242721,0.0001606509],"category_scores_gemma":[0.0009287497,0.00007736652,0.00003441705,0.0001301382,0.0001230826,0.00007256773,0.00005822265,0.0002731236,0.000004956873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002173556,"about_ca_system_score_gemma":0.00007715484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002874506,"about_ca_topic_score_gemma":0.00001810006,"domain_scores_codex":[0.998269,0.0002857627,0.0004343686,0.0001574758,0.0006801953,0.0001731618],"domain_scores_gemma":[0.9990988,0.0003082855,0.0002035082,0.0000798391,0.00003084539,0.0002787082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001697423,0.0004301853,0.06943365,0.00009085474,0.00002387782,0.0004154708,0.001368181,0.000159489,0.626065,0.0005287316,0.003728453,0.2975864],"study_design_scores_gemma":[0.00433007,0.001474053,0.6305174,0.0004040543,0.00005392681,0.0009639409,0.0001385469,0.01347979,0.2774254,0.00102923,0.069709,0.0004746295],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945837,0.001078856,0.0009068964,0.003123657,0.0001099071,0.00006976655,0.000001544856,0.00000442765,0.0001212806],"genre_scores_gemma":[0.9905658,0.004878195,0.002772776,0.001271501,0.0004297384,5.257913e-7,3.207779e-7,0.000008691907,0.00007240443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5610837,"threshold_uncertainty_score":0.3154915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180463517563162,"score_gpt":0.2787956066750193,"score_spread":0.2607492549187032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}