{"id":"W2144672824","doi":"10.1091/mbc.e14-04-0895","title":"The RNA-binding protein Staufen1 impairs myogenic differentiation via a c-myc–dependent mechanism","year":2014,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Institute of Musculoskeletal Health and Arthritis; Muscular Dystrophy Association","keywords":"Myogenesis; Biology; Cell biology; MyoD; MyoD Protein; Myocyte; C2C12; Myogenin; Skeletal muscle; Embryonic stem cell; Regeneration (biology); Gene knockdown; Cardiotoxin; Myogenic regulatory factors; Cell culture; Anatomy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174674,0.0005227079,0.0003128451,0.0004405616,0.0002303918,0.0002512867,0.0003202159,0.0005367156,0.00183564],"category_scores_gemma":[0.0001217669,0.0001771921,0.000343713,0.0002309923,0.0003286428,0.0001989058,0.0001922524,0.0005724145,0.0004495112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003765167,"about_ca_system_score_gemma":0.0002916352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276218,"about_ca_topic_score_gemma":0.001669254,"domain_scores_codex":[0.9998103,0.00003320786,0.00002351742,0.00003381512,0.00005639383,0.00004286597],"domain_scores_gemma":[0.9998447,0.00003764845,0.00005131726,0.00001760809,0.00001115037,0.00003743621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005934926,0.00002638288,0.00006840765,0.00002253922,0.000004637382,0.00002986833,0.00000528005,0.00004773597,0.9990469,0.00006493559,0.00002278015,0.0006011913],"study_design_scores_gemma":[0.0000107441,0.0002242411,0.003122958,0.000005573942,0.00001056707,0.0001290474,0.00001105685,0.0007339306,0.9942662,0.00003021353,0.001451926,0.000003410319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927809,0.00255018,0.002702659,0.000150118,0.00003257045,0.0000306327,0.0004884629,0.0001643584,0.001100187],"genre_scores_gemma":[0.9921162,0.001872018,0.001569321,0.00005181925,0.000008185018,0.0000585148,0.0006468853,0.00002688888,0.003650092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00183564,"threshold_uncertainty_score":0.006140828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003241095995847042,"score_gpt":0.2033113764387385,"score_spread":0.2000702804428915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}