{"id":"W2144708319","doi":"10.1016/j.ccr.2011.04.002","title":"c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma","year":2011,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"","keywords":"Oncogene; MAPK/ERK pathway; Cancer research; Kinase; Biology; Concomitant; Anti-apoptotic Ras signalling cascade; Lung; Carcinoma; clone (Java method); Cell; Medicine; Cell biology; Internal medicine; Cell cycle; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007939234,0.0002237121,0.000233841,0.00002944166,0.00009524605,0.00000996838,0.0003000893,0.0001975954,0.0001763439],"category_scores_gemma":[0.000003431486,0.000223149,0.0001538229,0.0000397102,0.00005505798,0.000003746535,0.0001341712,0.00005619324,0.00001216052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004384689,"about_ca_system_score_gemma":0.000606117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002319869,"about_ca_topic_score_gemma":0.000267952,"domain_scores_codex":[0.9987512,0.00001723225,0.0003241486,0.0004472661,0.0001077462,0.0003524632],"domain_scores_gemma":[0.9991908,0.000006919325,0.0001762842,0.0003619895,0.0001355338,0.0001284532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001659507,0.0001054103,0.003525651,0.0002877735,0.00004659699,0.000003265643,0.001700537,0.00000534631,0.9904621,0.000007208976,0.00281373,0.0008763963],"study_design_scores_gemma":[0.001106789,0.0001656847,0.001242484,0.00001614029,0.00006529082,0.000001281377,0.000148822,0.00008512684,0.9655505,0.000003541607,0.03133211,0.0002821898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840586,0.001279536,0.006223696,0.000008383688,0.0005089532,0.0004318629,0.0001479153,0.000008404032,0.007332688],"genre_scores_gemma":[0.9864321,0.0001070249,0.00899291,0.0001959641,0.0003359991,0.0001663036,0.0001049933,0.00004301784,0.003621645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02851838,"threshold_uncertainty_score":0.9099753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556869564990289,"score_gpt":0.2407732591841122,"score_spread":0.2152045635342093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}