{"id":"W2144708319","doi":"10.1016/j.ccr.2011.04.002","title":"c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma","year":2011,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"","keywords":"Oncogene; MAPK/ERK pathway; Cancer research; Kinase; Biology; Concomitant; Anti-apoptotic Ras signalling cascade; Lung; Carcinoma; clone (Java method); Cell; Medicine; Cell biology; Internal medicine; Cell cycle; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548989,0.0002894359,0.0001587217,0.0005190893,0.0003709116,0.0003608368,0.0002642918,0.0002733448,0.001829599],"category_scores_gemma":[0.0002130293,0.0002764337,0.0002173603,0.0001435926,0.0002420532,0.0002470538,0.0002807343,0.0008062031,0.0008549861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005533184,"about_ca_system_score_gemma":0.0004251536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00157305,"about_ca_topic_score_gemma":0.002757624,"domain_scores_codex":[0.9997818,0.00003245178,0.00002664441,0.0000311765,0.00007893265,0.00004899171],"domain_scores_gemma":[0.9996923,0.00007211253,0.00005237555,0.00005116042,0.00003733255,0.00009483643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006931376,0.00001932081,0.0001686894,0.000008153806,0.000001727463,0.0001097212,0.000006542433,0.00002895508,0.9989346,0.0001990886,0.00003726254,0.0004167088],"study_design_scores_gemma":[0.00001109599,0.00007513574,0.004704589,0.000002803119,0.000008192324,0.000835394,0.00002512464,0.001110949,0.9904906,0.00009643914,0.002636065,0.000003691295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930126,0.0008260848,0.002116111,0.0001615783,0.00002698143,0.00002197426,0.0004027183,0.0001131493,0.003318803],"genre_scores_gemma":[0.9944465,0.0003150243,0.001016148,0.00002507503,0.000004748425,0.00001480562,0.0004611714,0.00003247758,0.003683946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829599,"threshold_uncertainty_score":0.006120622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556869564990289,"score_gpt":0.2407732591841122,"score_spread":0.2152045635342093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}