{"id":"W2144712720","doi":"10.1158/1078-0432.ccr-11-1403","title":"Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Cancer Institute; National Institutes of Health","keywords":"Downregulation and upregulation; Abcg2; Dicer; Tamoxifen; Cancer research; Toremifene; Human breast; Breast cancer; Cancer; Medicine; Biology; Internal medicine; Cell culture; ATP-binding cassette transporter; Small interfering RNA; Transfection; Transporter; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881195,0.0002603395,0.0003087872,0.0002412822,0.0002053181,0.0002835217,0.0001672268,0.0003589713,0.001925554],"category_scores_gemma":[0.000235149,0.0001477564,0.0002208381,0.0002362806,0.000164467,0.0001623345,0.0002023232,0.0004154157,0.0007150413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245816,"about_ca_system_score_gemma":0.0001510572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997001,"about_ca_topic_score_gemma":0.0005140337,"domain_scores_codex":[0.9996852,0.00004801026,0.00003464367,0.00006746258,0.0001169308,0.00004782842],"domain_scores_gemma":[0.9998429,0.00002949779,0.00003616773,0.00004396307,0.00002576005,0.00002180036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004201772,0.00001379439,0.0001519701,0.00002800268,0.000004314744,0.00006161392,0.00001286281,0.00004395201,0.9987204,0.00004985562,0.00008622809,0.0007849858],"study_design_scores_gemma":[0.0000176664,0.0002716855,0.004210509,0.000004757128,0.00001503482,0.001001587,0.00002058429,0.0008239857,0.9888933,0.00002416274,0.004711677,0.000004936102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891933,0.002436283,0.004292515,0.0002151052,0.00004996243,0.0001007942,0.001088232,0.0001453932,0.002478491],"genre_scores_gemma":[0.9884892,0.001132615,0.004486668,0.0001037519,0.00001520334,0.00008304264,0.001892293,0.00002202691,0.003775128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001925554,"threshold_uncertainty_score":0.006441653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2371264051445465,"score_gpt":0.4819766399503201,"score_spread":0.2448502348057736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}