{"id":"W2144712720","doi":"10.1158/1078-0432.ccr-11-1403","title":"Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Cancer Institute; National Institutes of Health","keywords":"Downregulation and upregulation; Abcg2; Dicer; Tamoxifen; Cancer research; Toremifene; Human breast; Breast cancer; Cancer; Medicine; Biology; Internal medicine; Cell culture; ATP-binding cassette transporter; Small interfering RNA; Transfection; Transporter; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00241099,0.0001781553,0.0006566484,0.0002746559,0.00009401546,0.000009654027,0.0003090416,0.0003060651,0.002705784],"category_scores_gemma":[0.00008374228,0.000149655,0.0001766536,0.0007825322,0.0008030298,0.00009664797,0.00005323507,0.000913772,0.00002391225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138654,"about_ca_system_score_gemma":0.0007171838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00347839,"about_ca_topic_score_gemma":0.01153163,"domain_scores_codex":[0.9965553,0.0002852756,0.001031467,0.0005672858,0.0009447866,0.0006158333],"domain_scores_gemma":[0.9980483,0.0002512549,0.0001817889,0.0005271596,0.0006512342,0.0003402819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01486414,0.002980238,0.7762935,0.001971534,0.0003622845,0.000349966,0.003624987,0.00001422034,0.1786689,0.005213558,0.007031675,0.008624947],"study_design_scores_gemma":[0.00462386,0.0002658012,0.9559283,0.001268455,0.00006473546,9.501699e-7,0.0002670349,0.00003912535,0.03237323,0.001856785,0.003085261,0.0002264266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864177,0.001047661,0.00003018756,0.001125077,0.0003541636,0.0008352092,0.0001514537,0.00004155684,0.009997033],"genre_scores_gemma":[0.9940019,0.001431043,0.0002223874,0.0001191346,0.0002639474,0.0001546474,0.0000322825,0.00004416832,0.003730468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1796348,"threshold_uncertainty_score":0.9982059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2371264051445465,"score_gpt":0.4819766399503201,"score_spread":0.2448502348057736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}