{"id":"W2144744378","doi":"10.4049/jimmunol.175.2.730","title":"<i>Bordetella pertussis</i> Adenylate Cyclase Toxin Modulates Innate and Adaptive Immune Responses: Distinct Roles for Acylation and Enzymatic Activity in Immunomodulation and Cell Death","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; Enterprise Ireland","keywords":"Adenylate Cyclase Toxin; Bordetella pertussis; Biology; Inflammasome; Chemistry; Cell biology; Microbiology; Biochemistry; Pertussis toxin; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190816,0.0003298551,0.0002263267,0.0001253779,0.0001070377,0.0003560611,0.0001121885,0.0003054468,0.0006454471],"category_scores_gemma":[0.00007828447,0.00007809293,0.0002376276,0.0001457522,0.0002920804,0.0002193421,0.0001382301,0.0004155358,0.0002244253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004823377,"about_ca_system_score_gemma":0.0002176233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880792,"about_ca_topic_score_gemma":0.0006581753,"domain_scores_codex":[0.9998791,0.00002429326,0.00001035478,0.00001775405,0.00002457151,0.00004388277],"domain_scores_gemma":[0.9999442,0.00001171855,0.00001930416,0.000005080542,0.00000776963,0.0000119882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001433526,0.000008509873,0.0001654791,0.00002619923,0.000002239865,0.00003726852,0.000005065452,0.00002263036,0.9990863,0.00006523485,0.00001803334,0.0004197472],"study_design_scores_gemma":[0.00001783541,0.000313771,0.007609106,0.000007624202,0.00002166844,0.0002431134,0.00002947284,0.0004392904,0.9897379,0.00006359799,0.001512946,0.000003528946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940009,0.002469156,0.001252568,0.000251625,0.00003710125,0.00002203511,0.0002643741,0.00003782146,0.001664515],"genre_scores_gemma":[0.9966933,0.00110065,0.0007851708,0.0001315348,0.00002390916,0.00001889973,0.0002962342,0.000006919773,0.0009433796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006454471,"threshold_uncertainty_score":0.003499627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264825792189316,"score_gpt":0.2408648521865454,"score_spread":0.2282165942646522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}