{"id":"W2144744378","doi":"10.4049/jimmunol.175.2.730","title":"<i>Bordetella pertussis</i> Adenylate Cyclase Toxin Modulates Innate and Adaptive Immune Responses: Distinct Roles for Acylation and Enzymatic Activity in Immunomodulation and Cell Death","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; Enterprise Ireland","keywords":"Adenylate Cyclase Toxin; Bordetella pertussis; Biology; Inflammasome; Chemistry; Cell biology; Microbiology; Biochemistry; Pertussis toxin; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007824659,0.0001907048,0.0003955294,0.0002136512,0.0002574057,0.00002902775,0.0001026865,0.0002071523,0.0000171854],"category_scores_gemma":[0.0001375387,0.0001323476,0.00004912364,0.00008621824,0.0001844983,0.0003223887,0.00007488923,0.0003380104,0.000002255215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000460807,"about_ca_system_score_gemma":0.00003702212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001448024,"about_ca_topic_score_gemma":0.00013107,"domain_scores_codex":[0.9985917,0.0005328883,0.0004857526,0.0001444063,0.00001721328,0.0002279967],"domain_scores_gemma":[0.9985063,0.0007684474,0.0004511389,0.0001496341,0.000108177,0.00001629147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004345141,0.0001020737,0.002063552,0.00001515026,0.0001416625,6.473516e-7,0.00117688,0.00004619937,0.9692632,0.0001190129,0.00001026121,0.02271622],"study_design_scores_gemma":[0.006223402,0.001773624,0.7532958,0.0001274784,0.0002213637,0.0007716186,0.0007155181,0.001047826,0.23279,0.001256318,0.001473287,0.0003037132],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822366,0.01596362,0.0004627904,0.0008333388,0.0001871276,0.0002724967,0.00001963012,0.00001035235,0.00001406768],"genre_scores_gemma":[0.9970034,0.002522934,0.0002514818,0.00002068665,0.00004089857,0.000008519729,0.000006359576,0.000015125,0.0001305811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7512323,"threshold_uncertainty_score":0.5396978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264825792189316,"score_gpt":0.2408648521865454,"score_spread":0.2282165942646522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}