{"id":"W2144810965","doi":"10.4049/jimmunol.1003655","title":"Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide-Induced Lung Injury and Apoptosis","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); McGill University; Montreal General Hospital; Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"Canadian Institutes of Health Research","keywords":"STAT1; Apoptosis; PI3K/AKT/mTOR pathway; Proinflammatory cytokine; TLR4; Inflammation; Bronchoalveolar lavage; Biology; Cancer research; Signal transduction; Lung; Immunology; Cell biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788577,0.0008289049,0.001193927,0.0005950452,0.000174378,0.0003750327,0.0003980689,0.0004306509,0.001355369],"category_scores_gemma":[0.0001817134,0.0002053632,0.0004882812,0.0003160724,0.0003696874,0.0002822845,0.0002624725,0.001312468,0.0004960906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736447,"about_ca_system_score_gemma":0.0004557658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004874908,"about_ca_topic_score_gemma":0.0006568425,"domain_scores_codex":[0.9996495,0.00007355938,0.00004703169,0.00004366387,0.0000765955,0.0001095202],"domain_scores_gemma":[0.9997879,0.00004263044,0.00005601501,0.00002026034,0.00002674574,0.00006655215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002716698,0.0008358587,0.0002175009,0.0003892925,0.00006045088,0.000110003,0.00004543263,0.0004233024,0.9871044,0.0002171705,0.0004837863,0.007395996],"study_design_scores_gemma":[0.0002859787,0.00741574,0.004265409,0.00003906386,0.0001072195,0.0002926162,0.00005433761,0.002480109,0.9802614,0.0001057788,0.004671408,0.00002082847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861688,0.006830385,0.002433647,0.0003481653,0.0002534504,0.0001607076,0.0007134403,0.0006251881,0.002466126],"genre_scores_gemma":[0.9894302,0.004336478,0.002726793,0.0001668112,0.00007695862,0.0002214073,0.001229063,0.00004459838,0.001767677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001355369,"threshold_uncertainty_score":0.004534185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928024204059682,"score_gpt":0.2840803837690101,"score_spread":0.2648001417284133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}