{"id":"W2144835441","doi":"10.1093/hmg/ddq179","title":"A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Chromosome 21; Down syndrome; Genetics; Phenotype; Trisomy; Microcephaly; Human genetics; Intellectual disability; Chromosome 15; Mutant; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863443,0.001267021,0.0005741984,0.001561403,0.0005633488,0.0003751182,0.0008544038,0.001104629,0.005929748],"category_scores_gemma":[0.0001832144,0.0005243506,0.0006041615,0.0004581672,0.000622523,0.0005097642,0.0005605107,0.001631443,0.001233185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004229496,"about_ca_system_score_gemma":0.0004016933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007785666,"about_ca_topic_score_gemma":0.001325694,"domain_scores_codex":[0.9995863,0.00006168534,0.00006682535,0.0001214906,0.0001030718,0.00006068361],"domain_scores_gemma":[0.9996693,0.00006189589,0.00007386706,0.0000506484,0.00003187429,0.000112404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004829938,0.0002624583,0.0003657331,0.00007850896,0.00003577552,0.000604086,0.00007749905,0.000165668,0.9925572,0.00183519,0.000465201,0.003069702],"study_design_scores_gemma":[0.0006315816,0.002944455,0.004982381,0.00007408523,0.000277484,0.004772726,0.0001271086,0.003839729,0.9369362,0.001456271,0.04389041,0.00006752463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550825,0.002552882,0.02888087,0.0008348151,0.0005359619,0.000359778,0.004849846,0.001139037,0.005764395],"genre_scores_gemma":[0.8803703,0.003905929,0.05241343,0.0003575837,0.00009437951,0.001414282,0.009021203,0.0003260815,0.05209687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005929748,"threshold_uncertainty_score":0.01983696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06425870053167945,"score_gpt":0.3505802843316225,"score_spread":0.286321583799943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}