{"id":"W2144835441","doi":"10.1093/hmg/ddq179","title":"A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Chromosome 21; Down syndrome; Genetics; Phenotype; Trisomy; Microcephaly; Human genetics; Intellectual disability; Chromosome 15; Mutant; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002952497,0.0002773515,0.0005881969,0.000254674,0.0001419866,0.00003364429,0.0004155211,0.0002740876,0.0005358655],"category_scores_gemma":[0.0002471401,0.0002700764,0.0004384801,0.0001767066,0.0004596222,0.00003817593,0.0001438867,0.0004999837,0.00007959978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005675132,"about_ca_system_score_gemma":0.0001688537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003308601,"about_ca_topic_score_gemma":0.00004454666,"domain_scores_codex":[0.997785,0.00004986747,0.0005966198,0.0005182574,0.0004917476,0.000558471],"domain_scores_gemma":[0.9979787,0.00004377386,0.00009707877,0.001225517,0.0003353638,0.0003195648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005151559,0.0005542643,0.0002526123,0.0002497697,0.000178459,0.000009700628,0.0002426724,0.00007526043,0.9943033,0.002556714,0.001444248,0.00008146247],"study_design_scores_gemma":[0.007143727,0.007572829,0.004798193,0.0002191059,0.0009934769,0.0006811297,0.0001846308,0.0216855,0.9253629,0.02647763,0.003666489,0.001214356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938834,0.0001596615,0.002314022,0.0002283775,0.00004254503,0.001304996,0.00007556136,0.00005996343,0.00193143],"genre_scores_gemma":[0.9920545,0.00003738882,0.002542103,0.0002083576,0.00003928314,0.0001326287,0.0001459889,0.00009408247,0.004745728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06894039,"threshold_uncertainty_score":0.9999751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06425870053167945,"score_gpt":0.3505802843316225,"score_spread":0.286321583799943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}