{"id":"W2144855932","doi":"10.1074/jbc.m113.494542","title":"Mechanism and Function of Monoclonal Antibodies Targeting Siglec-15 for Therapeutic Inhibition of Osteoclastic Bone Resorption","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alethia Biotherapeutics (Canada)","funders":"","keywords":"SIGLEC; Osteoclast; RANKL; Monoclonal antibody; RANK Ligand; Bone resorption; Cell biology; Chemistry; Receptor; Antibody; Cancer research; Biology; Immunology; Activator (genetics); Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004646019,0.0004064427,0.0003659324,0.000362275,0.0001394374,0.0003474197,0.000428205,0.0004253158,0.0007030342],"category_scores_gemma":[0.0001465584,0.0001774537,0.0004849905,0.0001308478,0.0002120143,0.0002277148,0.0001817552,0.0004611918,0.0002624519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005306099,"about_ca_system_score_gemma":0.000344782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004994384,"about_ca_topic_score_gemma":0.0005602476,"domain_scores_codex":[0.9997709,0.00004811228,0.00001745254,0.00002744942,0.00005950345,0.00007659743],"domain_scores_gemma":[0.999948,0.000009362315,0.0000166088,0.000005253516,0.0000086626,0.00001212259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002837789,0.0001783003,0.0002702258,0.0002337691,0.00003447594,0.0001194627,0.00002054253,0.0004325635,0.9834254,0.001383526,0.000197838,0.01341999],"study_design_scores_gemma":[0.0002670742,0.002201583,0.004963567,0.00003420711,0.0001133233,0.00122787,0.00002262319,0.004301907,0.9757199,0.0003490832,0.01078336,0.00001568531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297404,0.03574521,0.02609458,0.0005838657,0.0001593541,0.0004280702,0.0003260931,0.0003677997,0.006554576],"genre_scores_gemma":[0.9885913,0.004975855,0.004172326,0.0001890119,0.00002173192,0.0001243196,0.0001357071,0.00001201291,0.001777819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007030342,"threshold_uncertainty_score":0.003849924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513081285514208,"score_gpt":0.2360813106986581,"score_spread":0.220950497843516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}