{"id":"W2144879037","doi":"10.1093/hmg/ddv188","title":"CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Hotel Dieu Hospital; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrial fission; Cyclin-dependent kinase 5; Biology; Cell biology; DNAJA3; Mitochondrion; Mitochondrial apoptosis-induced channel; Phosphorylation; Programmed cell death; mitochondrial fusion; Apoptosis; Mitochondrial DNA; Protein kinase A; Cytochrome c; Biochemistry; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000117836,0.0002713368,0.0002302679,0.0001025893,0.00007360866,0.00004813276,0.0001943089,0.0002918831,0.00002150153],"category_scores_gemma":[0.0001153705,0.0002921138,0.00008670663,0.00009912279,0.00009018347,0.000003907826,0.0001888861,0.0001850496,0.00001925006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001713964,"about_ca_system_score_gemma":0.00009702129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002031044,"about_ca_topic_score_gemma":0.00009704717,"domain_scores_codex":[0.9983621,0.0001906628,0.0002900865,0.000598234,0.0001921123,0.0003668419],"domain_scores_gemma":[0.9991451,0.00001098573,0.00008166495,0.0004221842,0.00009248863,0.00024758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009698526,0.00006198631,0.009274972,0.000007230668,0.000019839,0.00003965466,0.0001185189,0.0001337305,0.9886401,0.0004284375,0.0008443123,0.0003342237],"study_design_scores_gemma":[0.004513773,0.002156359,0.03254064,0.00002317523,0.00005828393,0.0000952464,0.0001283019,0.0001509589,0.9352971,0.002536475,0.02166523,0.0008344284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946459,0.001492826,0.001477844,0.00003561017,0.0006583036,0.000301717,0.00000652542,0.00002101417,0.001360252],"genre_scores_gemma":[0.9954652,0.00009967142,0.003006748,0.0005238868,0.0003747986,0.00003209695,0.0001060976,0.00005222464,0.0003392416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05334299,"threshold_uncertainty_score":0.9999531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02717080055643298,"score_gpt":0.2703551545744213,"score_spread":0.2431843540179883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}