{"id":"W2144921015","doi":"10.1016/s1470-2045(15)00363-0","title":"Intravenous pegylated asparaginase versus intramuscular native Escherichia coli l-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McMaster University","funders":"National Cancer Institute; Dana-Farber Cancer Institute; Enzon Pharmaceuticals","keywords":"Medicine; Asparaginase; Internal medicine; Gastroenterology; Pediatrics; Surgery; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001322864,0.001807812,0.002903421,0.0004277538,0.0002806294,0.00124949,0.00127358,0.001874808,0.008497488],"category_scores_gemma":[0.00169044,0.0006879544,0.001868348,0.0005245883,0.001362009,0.001079969,0.0004276571,0.004412461,0.00133722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001419951,"about_ca_system_score_gemma":0.001383434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002255006,"about_ca_topic_score_gemma":0.003756854,"domain_scores_codex":[0.9995433,0.0002371477,0.0000185697,0.00007420695,0.00003069313,0.00009600326],"domain_scores_gemma":[0.9991887,0.0002765336,0.0001347771,0.00006130898,0.00002758815,0.0003109856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.972063,0.003741519,0.0003537249,0.0005727186,0.0005944998,0.00005340391,0.00006346506,0.0004335218,0.001912424,0.0001934801,0.001097528,0.01892069],"study_design_scores_gemma":[0.9634199,0.03482131,0.0005794709,0.00002236652,0.00017005,0.00003039609,0.00002152692,0.0001999802,0.00019052,0.0001185312,0.0004177805,0.000008088777],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831312,0.006576048,0.0008208137,0.001177577,0.0008181114,0.002820435,0.001579848,0.0002521976,0.002823675],"genre_scores_gemma":[0.981482,0.005074706,0.001641391,0.001606295,0.0003482017,0.003113414,0.001703422,0.00004829316,0.004982235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008497488,"threshold_uncertainty_score":0.02842689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07495321031302048,"score_gpt":0.3856600473002791,"score_spread":0.3107068369872586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}