{"id":"W2144921015","doi":"10.1016/s1470-2045(15)00363-0","title":"Intravenous pegylated asparaginase versus intramuscular native Escherichia coli l-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McMaster University","funders":"National Cancer Institute; Dana-Farber Cancer Institute; Enzon Pharmaceuticals","keywords":"Medicine; Asparaginase; Internal medicine; Gastroenterology; Pediatrics; Surgery; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003619126,0.0007561714,0.00269937,0.0003881197,0.0002432162,0.0001670725,0.001748486,0.0006496086,0.0002334759],"category_scores_gemma":[0.005405413,0.0005585136,0.0001534865,0.001511938,0.0008915167,0.0003188599,0.000801847,0.001699272,0.0003896162],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.005556528,"about_ca_system_score_gemma":0.009747946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600139,"about_ca_topic_score_gemma":0.000430347,"domain_scores_codex":[0.9928363,0.002071396,0.001176203,0.001085104,0.001011974,0.001819009],"domain_scores_gemma":[0.9931251,0.003453036,0.0005213849,0.00138408,0.0005311613,0.0009852406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9190345,0.01102784,0.00002487761,0.00006567723,0.001742557,0.01461007,0.0049272,0.0002686861,0.001794108,0.0005205336,0.03444077,0.01154321],"study_design_scores_gemma":[0.9497923,0.02157588,0.0002322552,0.0001365389,0.001031292,0.0006629527,0.0006938564,0.01155774,0.0006454264,0.0004442022,0.01263896,0.000588647],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760786,0.0005388503,0.0004444482,0.006615662,0.001721826,0.008254257,0.0001094784,0.0002038323,0.006033089],"genre_scores_gemma":[0.9892966,0.0004554458,0.001854471,0.00330694,0.001940688,0.002089414,0.0003982778,0.0001581172,0.0005000377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03075779,"threshold_uncertainty_score":0.9996867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07495321031302048,"score_gpt":0.3856600473002791,"score_spread":0.3107068369872586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}