{"id":"W2144948193","doi":"10.1124/dmd.113.054304","title":"Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4","year":2013,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; Queen's University; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Cholestasis; Multidrug resistance-associated protein 2; Bile Salt Export Pump; Pharmacology; Bile acid; Internal medicine; Transporter; Drug; Medicine; ATP-binding cassette transporter; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002679236,0.000348154,0.0004810058,0.0003509294,0.0003339995,0.0006230497,0.000179671,0.0005934807,0.002244907],"category_scores_gemma":[0.0008786019,0.0002183538,0.0005771602,0.0005294124,0.0001844921,0.0003191385,0.0002557164,0.0009674283,0.0003177653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734978,"about_ca_system_score_gemma":0.0003777268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004831,"about_ca_topic_score_gemma":0.001041354,"domain_scores_codex":[0.9997768,0.00006193999,0.00002301935,0.00004059854,0.00005143372,0.00004616093],"domain_scores_gemma":[0.9991842,0.000113764,0.0003563835,0.0000771122,0.00008233954,0.0001862557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001738079,0.0001669138,0.9866833,0.00004703825,0.0003161788,0.0003576068,0.00003532294,0.00006151142,0.003975929,0.0001333523,0.000198668,0.006286009],"study_design_scores_gemma":[0.00002947003,0.000417243,0.9952086,0.0000128458,0.0004443304,0.001015742,0.00007329547,0.0004312903,0.001546312,0.0001601363,0.0006527398,0.000007887291],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924923,0.003187045,0.0009439114,0.0004082908,0.0000428452,0.00001341735,0.0002280198,0.00003811465,0.002646095],"genre_scores_gemma":[0.9985833,0.0003490643,0.0002508327,0.00003772049,0.00003822628,0.000004354018,0.00008755284,0.000005062926,0.0006439211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244907,"threshold_uncertainty_score":0.007510006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00860911997080299,"score_gpt":0.2216605008239663,"score_spread":0.2130513808531633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}