{"id":"W2144953100","doi":"10.4049/jimmunol.170.2.711","title":"Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"CD28; STAT5; Cell biology; Cytokine; Interleukin 10; Receptor; Interleukin 15; Stimulation; Signal transduction; Chemistry; T cell; Immunology; Biology; Cancer research; Interleukin; Immune system; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182045,0.0005033385,0.0002383603,0.0001733959,0.0001085932,0.000353191,0.0001506973,0.0002087035,0.001049607],"category_scores_gemma":[0.0001260585,0.0001006896,0.0002438707,0.0001104497,0.0001898365,0.0001475985,0.0002037916,0.0007621882,0.0002452979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211638,"about_ca_system_score_gemma":0.0002218388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002212566,"about_ca_topic_score_gemma":0.0003774636,"domain_scores_codex":[0.9997993,0.00003433017,0.00001575982,0.00002263902,0.0000444112,0.00008354901],"domain_scores_gemma":[0.9998764,0.00002937649,0.00002921874,0.00001595151,0.000009355611,0.00003973741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002250533,0.0000700871,0.0001543016,0.00002974098,0.000003050219,0.00003014946,0.00001810981,0.00006857913,0.9978778,0.00006693373,0.00001578206,0.001440306],"study_design_scores_gemma":[0.00002865882,0.0008188901,0.003031988,0.00000578708,0.00001406091,0.0001473699,0.00001743286,0.0004800191,0.9946039,0.00002605663,0.000823365,0.00000233734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977974,0.0005445297,0.0006515319,0.00002136391,0.0000143833,0.00001314875,0.00006783458,0.00002521167,0.0008646302],"genre_scores_gemma":[0.9974065,0.0004756458,0.0007495579,0.00003089161,0.00001391223,0.00003948648,0.0002593886,0.000008735926,0.001015721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049607,"threshold_uncertainty_score":0.00351131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02777328871548423,"score_gpt":0.2700183172761803,"score_spread":0.2422450285606961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}