{"id":"W2144953100","doi":"10.4049/jimmunol.170.2.711","title":"Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"CD28; STAT5; Cell biology; Cytokine; Interleukin 10; Receptor; Interleukin 15; Stimulation; Signal transduction; Chemistry; T cell; Immunology; Biology; Cancer research; Interleukin; Immune system; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104608,0.0002270533,0.0003739505,0.00026871,0.0004483804,0.00004263326,0.00009421659,0.0002388516,0.00005312661],"category_scores_gemma":[0.0009536627,0.0001670686,0.00005755536,0.0001101689,0.0002294426,0.0002938457,0.0000485916,0.0005847851,0.00001155865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008729655,"about_ca_system_score_gemma":0.00007441067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002162518,"about_ca_topic_score_gemma":0.000006990309,"domain_scores_codex":[0.9971856,0.001705539,0.0006082202,0.0001941825,0.00008829461,0.0002181413],"domain_scores_gemma":[0.9975672,0.001153125,0.0007482059,0.000201788,0.0003071603,0.00002245898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007015428,0.0002355675,0.002812998,0.00004146868,0.0003600233,0.000002600124,0.0009734941,0.0000635692,0.9632424,0.000600618,0.0003234612,0.02432842],"study_design_scores_gemma":[0.004389272,0.005991684,0.1904044,0.00019699,0.0002588283,0.0007117928,0.0005577176,0.0001647449,0.772006,0.0001578924,0.02494342,0.0002172326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951065,0.0009251144,0.00102566,0.001185328,0.0009520836,0.0006794288,0.000009265665,0.00002541176,0.00009119856],"genre_scores_gemma":[0.9984827,0.0006991301,0.0001493024,0.0001466176,0.00005217592,0.00002177695,0.00004274567,0.0000180432,0.0003875245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1912363,"threshold_uncertainty_score":0.6812859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02777328871548423,"score_gpt":0.2700183172761803,"score_spread":0.2422450285606961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}