{"id":"W2144968985","doi":"10.1093/oxfordjournals.jbchem.a002916","title":"Efficient Transfer of Intact Oligonucleotides into the Nucleus of Ligament Scar Fibroblasts by HVJ-Cationic Liposomes Is Correlated with Effective Antisense Gene Inhibition","year":2001,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Research Centre of Canada; University of Calgary","funders":"","keywords":"Cationic liposome; Liposome; Transfection; Decorin; Molecular biology; Oligonucleotide; Chemistry; Small interfering RNA; Biophysics; Biology; Cell biology; Biochemistry; Gene; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843848,0.0001582495,0.0002148485,0.00003299285,0.00006531256,0.00001136098,0.0002252486,0.000108106,0.00001585011],"category_scores_gemma":[0.00002779158,0.00009178314,0.0001427569,0.0001441567,0.0002426386,0.000004736326,0.00004269805,0.0001543108,0.000001639527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002873213,"about_ca_system_score_gemma":0.00008832485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003335323,"about_ca_topic_score_gemma":0.000003207976,"domain_scores_codex":[0.9990069,0.00007353356,0.0004189189,0.0001343517,0.0002258647,0.000140394],"domain_scores_gemma":[0.9989801,0.00004115371,0.0003171712,0.0002816258,0.000329006,0.00005094592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009130698,0.0001472306,0.0003463089,0.00004204354,0.0002506416,0.000003205709,0.0007491413,0.001167548,0.994496,5.080777e-7,0.0005549782,0.001329301],"study_design_scores_gemma":[0.0006828202,0.001015913,0.0007317149,0.0003092174,0.0001333242,0.0002253032,0.0005477966,0.0001290444,0.9960374,0.00001011254,0.00007216525,0.0001051928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966658,0.002249469,0.0005457258,0.0002540846,0.0000431043,0.0001467321,0.00002562993,0.00000241345,0.00006707313],"genre_scores_gemma":[0.9982078,0.001496446,0.000053875,0.00008208039,0.00006824402,0.000002506461,0.00001141872,0.0000148139,0.00006279512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542052,"threshold_uncertainty_score":0.3742808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002795706250928813,"score_gpt":0.202255775804907,"score_spread":0.1994600695539782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}