{"id":"W2145017630","doi":"10.1002/jps.20614","title":"Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cimetidine**This paper reflects the scientific opinion of the authors and not the policies of regulating agencies.","year":2006,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Rijksinstituut voor Volksgezondheid en Milieu; Royal Golden Jubilee (RGJ) Ph.D. Programme; Thailand Research Fund","keywords":"Biopharmaceutics Classification System; Bioequivalence; Cimetidine; Pharmacology; Dosage form; Excipient; Bioavailability; Biopharmaceutics; Dissolution testing; Medicine; Drug; Pharmacokinetics; Immediate release; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001796538,0.001111457,0.0005625659,0.003194209,0.0008099503,0.00112931,0.001271085,0.002579298,0.0243613],"category_scores_gemma":[0.002737605,0.0004708311,0.000348521,0.00181348,0.0006035886,0.00100203,0.0006127569,0.002313676,0.02137216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006762449,"about_ca_system_score_gemma":0.001891026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00257226,"about_ca_topic_score_gemma":0.00757585,"domain_scores_codex":[0.9989861,0.0002113587,0.000157728,0.00007970278,0.0005083362,0.00005678056],"domain_scores_gemma":[0.9963851,0.001015204,0.000840742,0.0002801769,0.001258555,0.0002202311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000307325,0.0002679416,0.0004632961,0.001667305,0.00001547971,0.000388383,0.0001516573,0.0003756186,0.02714878,0.00481265,0.524837,0.4395646],"study_design_scores_gemma":[0.000012902,0.0001615688,0.001256039,0.0001657251,0.000008651127,0.0003321984,0.00001210025,0.0001221125,0.00300604,0.0003700408,0.9945436,0.000009043833],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.01822102,0.2292819,0.03781418,0.05343319,0.04009526,0.002192728,0.007177732,0.003767937,0.608016],"genre_scores_gemma":[0.03511436,0.08381355,0.01302279,0.01532935,0.01529006,0.0009880755,0.004293153,0.0007576849,0.8313911],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0243613,"threshold_uncertainty_score":0.08149672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1734294499812272,"score_gpt":0.4601781683277411,"score_spread":0.2867487183465138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}