{"id":"W2145031719","doi":"10.1172/jci12433","title":"CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects","year":2001,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba","funders":"Medical Research Council; Ontario HIV Treatment Network; Medical Research Council Canada; Elizabeth Glaser Pediatric AIDS Foundation","keywords":"Epitope; CTL*; Immunology; Cytotoxic T cell; Seroconversion; Virology; CD8; Biology; Immunodominance; HIV vaccine; Human leukocyte antigen; Medicine; Immune system; Antibody; Antigen; Genetics; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002930681,0.0003718446,0.0002484894,0.0005890536,0.0004262649,0.0004618213,0.0001632944,0.0005392241,0.001331101],"category_scores_gemma":[0.00090566,0.0002701601,0.0001039531,0.0002007111,0.0004007087,0.0002265654,0.0002825538,0.0003572362,0.0003481939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158879,"about_ca_system_score_gemma":0.0001118583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208378,"about_ca_topic_score_gemma":0.001083155,"domain_scores_codex":[0.9997925,0.00004757274,0.00001613101,0.00004842894,0.00002375002,0.00007173207],"domain_scores_gemma":[0.9997472,0.00009289369,0.00003750232,0.00001890591,0.00001668834,0.00008674992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003245902,0.0004792004,0.9345816,0.00005780656,0.00005402075,0.001648085,0.001976175,0.0001195286,0.04526157,0.0001156781,0.0002308109,0.0122296],"study_design_scores_gemma":[0.0001091794,0.001846348,0.9920461,0.00001557747,0.00003433392,0.002410291,0.0007978169,0.0001502244,0.001940202,0.0001139591,0.0005271752,0.00000870613],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996687,0.00007939086,0.00001018728,0.000007916084,0.000001794964,0.000003309694,0.00001728285,0.000001503167,0.0002098202],"genre_scores_gemma":[0.9995259,0.00005885661,0.00002184888,0.00004372972,0.000007360147,0.000007063726,0.00006525447,0.000001124242,0.0002688414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331101,"threshold_uncertainty_score":0.004452944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06228032774418948,"score_gpt":0.3669350010936809,"score_spread":0.3046546733494915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}