{"id":"W2145035318","doi":"10.2967/jnumed.111.095653","title":"Quantitative Preclinical Imaging of TSPO Expression in Glioma Using <i>N,N</i>-Diethyl-2-(2-(4-(2-<sup>18</sup>F-Fluoroethoxy)Phenyl)-5,7-Dimethylpyrazolo[1,5-<i>a</i>]Pyrimidin-3-yl)Acetamide","year":2012,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; McGill University","keywords":"Translocator protein; Radioligand; In vivo; Chemistry; Molecular imaging; Glioma; Nuclear medicine; In vitro; Pathology; Cancer research; Medicine; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003986247,0.0004637385,0.001887654,0.000861477,0.0001109176,0.00001170073,0.0003731941,0.0002796889,0.0008568529],"category_scores_gemma":[0.0009582226,0.0003307871,0.000459849,0.0007544704,0.0005805299,0.000607051,0.00008195618,0.001269958,0.00001290549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001991874,"about_ca_system_score_gemma":0.0002022915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005066357,"about_ca_topic_score_gemma":0.000002831111,"domain_scores_codex":[0.9947517,0.000336742,0.002409671,0.0003608994,0.001351247,0.0007897393],"domain_scores_gemma":[0.9964232,0.0004894797,0.001376606,0.0004888112,0.0005405257,0.0006814046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004818652,0.001159389,0.02065464,0.0005973142,0.0002306022,0.000723018,0.008778621,0.0002475626,0.9572996,0.0003736086,0.0027841,0.002332888],"study_design_scores_gemma":[0.0745164,0.0138254,0.2796589,0.05712183,0.007197179,0.008684112,0.1016157,0.02146284,0.3922581,0.003087787,0.03712847,0.003443219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829872,0.009590835,0.001491509,0.002574124,0.0009363461,0.0004339092,0.000006878573,0.00004025529,0.001938967],"genre_scores_gemma":[0.9623968,0.0006213532,0.0351661,0.000640873,0.0009860225,0.000002059596,0.000006094903,0.0001175474,0.00006317679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5650415,"threshold_uncertainty_score":0.9999144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07201743405432284,"score_gpt":0.3676449060000661,"score_spread":0.2956274719457432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}