{"id":"W2145036730","doi":"10.1016/s1474-4422(07)70174-6","title":"Deciphering the role of heterozygous mutations in genes associated with parkinsonism","year":2007,"lang":"en","type":"review","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre; Toronto Western Hospital","funders":"National Institutes of Health; Volkswagen Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Parkin; Parkinsonism; PINK1; Genetics; Mutation; Loss of heterozygosity; Parkinson's disease; Biology; Disease; Compound heterozygosity; Gene; Medicine; Allele; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000308242,0.0002631958,0.001300154,0.00009607788,0.00007051495,0.00000790202,0.0002539654,0.0001823901,0.00001691434],"category_scores_gemma":[0.00006044255,0.0001244896,0.0001713829,0.0002990846,0.0001280444,0.00001405268,0.00005812698,0.0004413532,0.00001244349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003497727,"about_ca_system_score_gemma":0.0001229587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005543201,"about_ca_topic_score_gemma":0.0002003542,"domain_scores_codex":[0.9985029,0.0003311044,0.0003418535,0.0002736744,0.0001781528,0.0003722863],"domain_scores_gemma":[0.9985787,0.0005166078,0.0003140957,0.0005066598,0.00003316295,0.00005078232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002324172,0.0002715274,0.002227697,0.000501868,0.0007001339,0.0006439151,0.0001455406,0.00001990728,0.000004780328,0.0002315833,0.00002118069,0.9949995],"study_design_scores_gemma":[0.001052724,0.000385147,0.004731989,0.0008486069,0.001230908,0.000320329,0.00000953088,0.00003495872,0.00000945528,0.0004968458,0.9907613,0.0001182153],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01565719,0.9826052,0.00001625461,0.000167507,0.00009294027,0.0007946221,0.0000511619,0.00003629018,0.0005788392],"genre_scores_gemma":[0.0527884,0.9462207,0.00003528993,0.0004793592,0.0001447183,0.0001737461,0.00006999946,0.00005214667,0.00003566204],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9948812,"threshold_uncertainty_score":0.5076538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06353779093659583,"score_gpt":0.3335439101097914,"score_spread":0.2700061191731956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}