{"id":"W2145045034","doi":"10.1152/ajpheart.00416.2012","title":"Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ<sub>2</sub>","year":2012,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Protein kinase C; Kinase; Cell biology; Oxidative phosphorylation; Loop (graph theory); Diabetes mellitus; Internal medicine; Chemistry; Biology; Endocrinology; Medicine; Biochemistry; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003853131,0.000291158,0.0006561058,0.0001678922,0.0001195897,0.00001190277,0.000166888,0.0001449364,0.000007333553],"category_scores_gemma":[0.0001967397,0.0002703178,0.0001106347,0.0002627981,0.0007730573,0.00005559049,0.0001683314,0.0003887095,0.000002610598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005327057,"about_ca_system_score_gemma":0.0001434977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003593359,"about_ca_topic_score_gemma":0.000002416157,"domain_scores_codex":[0.9977115,0.0006318781,0.0003903845,0.0004929899,0.0001449539,0.0006283089],"domain_scores_gemma":[0.9986145,0.0001379448,0.0003626638,0.0003111567,0.0002881011,0.0002855879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002634416,0.0001431499,0.01314364,0.00003676749,0.0001896862,4.55699e-7,0.000293504,0.00001215232,0.9845161,0.00001274319,0.0002737147,0.001114673],"study_design_scores_gemma":[0.0006937228,0.000742746,0.3776344,0.00002753503,0.00002632426,0.0000197365,0.0009169524,0.00001818923,0.6194266,0.0001222813,0.0001463221,0.0002251871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964255,0.003059038,0.000003636338,0.0001793215,0.00008289784,0.0001922432,0.00004120414,0.000005672097,0.00001049209],"genre_scores_gemma":[0.9982148,0.0005148465,0.00008400491,0.00072559,0.0003415194,0.00001508418,0.00006701412,0.00003218284,0.000004989865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3650895,"threshold_uncertainty_score":0.9999749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007914135573956753,"score_gpt":0.2521772599577742,"score_spread":0.2442631243838174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}