{"id":"W2145078609","doi":"10.1002/jnr.22748","title":"Neutral sphingomyelinase activation precedes NADPH oxidase‐dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor‐α","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; McGill University; Pennsylvania State University","keywords":"Ceramide; Sphingomyelin; Sphingosine kinase; Sphingomyelin phosphodiesterase; Lipid signaling; NADPH oxidase; Cell biology; Neurite; Proinflammatory cytokine; Reactive oxygen species; Oxidative stress; Sphingosine; Biology; Sphingolipid; Neurodegeneration; Chemistry; Biochemistry; Inflammation; Sphingosine-1-phosphate; Internal medicine; Apoptosis; Immunology; Medicine; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002150631,0.0001429861,0.0001742466,0.0003399383,0.0002460212,0.0001237747,0.0009206102,0.00005552021,0.00001103961],"category_scores_gemma":[0.001625413,0.0001012026,0.00009139111,0.000584751,0.0001678214,0.00005762051,0.0002720152,0.0005706272,0.000003405376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003499129,"about_ca_system_score_gemma":0.000346278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005192835,"about_ca_topic_score_gemma":0.00007170891,"domain_scores_codex":[0.9976498,0.0004247502,0.0004376227,0.0003404612,0.0006116686,0.0005356526],"domain_scores_gemma":[0.9988211,0.0000636742,0.0001803818,0.0003752262,0.0003097505,0.000249836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002551207,0.0001120685,0.002942062,0.00001023322,0.000002293715,0.0000501898,0.0005189853,0.0001928219,0.9952013,0.00002920619,0.0001569895,0.0005287417],"study_design_scores_gemma":[0.0003844569,0.0005466394,0.1477862,0.00003252018,0.000002808533,0.00005557653,0.0002124977,0.00009238343,0.8487778,0.00003761912,0.001974484,0.00009706716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984936,0.00003502133,0.000292896,0.0004405548,0.000295121,0.000333478,0.000007140071,0.000004299666,0.0000978898],"genre_scores_gemma":[0.9989572,0.00006967177,0.0001814317,0.0002948595,0.0003511234,0.00001517072,7.36367e-7,0.00001961314,0.0001101668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1464235,"threshold_uncertainty_score":0.412692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1129042315816282,"score_gpt":0.3432639462808318,"score_spread":0.2303597146992037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}