{"id":"W2145080853","doi":"10.1126/science.1083653","title":"Assembly of Cell Regulatory Systems Through Protein Interaction Domains","year":2003,"lang":"en","type":"review","venue":"Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1437,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Computational biology; Flexibility (engineering); Protein–protein interaction; Biology; Modular design; Nucleic acid; Cell biology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004654903,0.001185329,0.001372983,0.001416501,0.0005187221,0.001368867,0.001182689,0.001178088,0.002130281],"category_scores_gemma":[0.0002416531,0.0004306037,0.0003810181,0.001341296,0.001013523,0.001497057,0.0006544368,0.0009543616,0.00507191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001147733,"about_ca_system_score_gemma":0.0008425496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008352,"about_ca_topic_score_gemma":0.0009935602,"domain_scores_codex":[0.9998184,0.00002517072,0.00001640175,0.00004897687,0.00007091942,0.00002014512],"domain_scores_gemma":[0.9998945,0.00002808923,0.00002437776,0.00001055937,0.00002914894,0.00001314584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007955635,0.0000555635,0.0004163143,0.009014852,0.00008214674,0.0006745235,0.0002070981,0.001366349,0.03769505,0.04308363,0.01969261,0.8876323],"study_design_scores_gemma":[0.00001304684,0.00004756452,0.0004440663,0.000647991,0.00003412392,0.001137904,0.00005051309,0.0002137897,0.007680102,0.0063683,0.9833452,0.00001737416],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009791912,0.9852167,0.003423363,0.0003055196,0.0002357959,0.00003039933,0.00004534406,0.00009362645,0.009669982],"genre_scores_gemma":[0.006671035,0.9844321,0.002862623,0.0003136979,0.0001582317,0.00005321537,0.0001479212,0.00001079246,0.005350368],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002130281,"threshold_uncertainty_score":0.008327425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03843883939225787,"score_gpt":0.320829016318112,"score_spread":0.2823901769258541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}