{"id":"W2145122616","doi":"10.1186/1742-5573-8-2","title":"Disease-specific prospective family study cohorts enriched for familial risk","year":2011,"lang":"en","type":"article","venue":"Epidemiologic Perspectives & Innovations","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Norris Cotton Cancer Center; National Institutes of Health; University of Melbourne; Huntsman Cancer Institute; Cancer Care Ontario","keywords":"Family aggregation; Medicine; Quartile; Epidemiology; First-degree relatives; Family history; Disease; Demography; Risk factor; Prospective cohort study; Genetics; Internal medicine; Confidence interval; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001175851,0.0003338287,0.0003804185,0.0001708774,0.000514125,0.00002021424,0.0003685976,0.000168216,0.00005869929],"category_scores_gemma":[0.00253633,0.0003070005,0.0001941715,0.0006220342,0.0003506085,0.00001642119,0.0001394661,0.0002458296,0.00001773208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642708,"about_ca_system_score_gemma":0.0002724745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007427735,"about_ca_topic_score_gemma":0.0000370915,"domain_scores_codex":[0.9973645,0.0003363095,0.0005964332,0.001107673,0.000152172,0.000442928],"domain_scores_gemma":[0.9977275,0.0001667102,0.0003505892,0.0007875014,0.0008623493,0.0001053945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001244898,0.002538241,0.8662329,0.0000136392,0.001018483,0.000008230785,0.009367088,0.0004210896,0.0383292,0.05171438,0.02702172,0.002090127],"study_design_scores_gemma":[0.001062182,0.0008275535,0.9595195,0.00000412981,0.0000869335,0.000002311951,0.01486816,0.00005712062,0.0004906335,0.01867993,0.003988297,0.0004132275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9292411,0.002279216,0.06109869,0.000212181,0.000482655,0.002422455,0.0003141541,0.0001024744,0.003847109],"genre_scores_gemma":[0.982514,0.000363177,0.0136861,0.0002885584,0.0006038229,0.001937518,0.0001857423,0.00004459343,0.000376506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09328662,"threshold_uncertainty_score":0.9999382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07023876128160132,"score_gpt":0.3209852902973286,"score_spread":0.2507465290157273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}