{"id":"W2145160468","doi":"10.1093/humupd/dmh002","title":"Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology","year":2004,"lang":"en","type":"review","venue":"Human Reproduction Update","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital","funders":"","keywords":"Genomic imprinting; Reprogramming; Biology; Imprinting (psychology); Epigenetics; Germ cell; Genetics; Assisted reproductive technology; Epigenesis; DNA methylation; Infertility; Gene; Pregnancy; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004416401,0.0005580205,0.000854607,0.001277981,0.0002122368,0.0006656579,0.0006255195,0.001092316,0.003992111],"category_scores_gemma":[0.0008201631,0.0001350534,0.0002224823,0.001523006,0.0005598422,0.0009146721,0.0003586354,0.0007344553,0.002043545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006100063,"about_ca_system_score_gemma":0.0009117454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055474,"about_ca_topic_score_gemma":0.00153331,"domain_scores_codex":[0.9998267,0.00003918052,0.00002118576,0.00002605742,0.00007213152,0.00001471281],"domain_scores_gemma":[0.999661,0.0001936906,0.00004461883,0.00001317429,0.00005837752,0.00002923664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006115967,0.00003230516,0.000612232,0.004798471,0.00006297533,0.001855737,0.00007880216,0.0002937636,0.003643318,0.008083398,0.02001701,0.9604607],"study_design_scores_gemma":[0.00002102668,0.00008774388,0.002746431,0.001367407,0.00008524216,0.01139297,0.0001234343,0.0000809409,0.001490456,0.004910667,0.9776736,0.00001998985],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003270764,0.9963377,0.0003096458,0.0004791169,0.0002249147,0.000003264314,0.00001332222,0.00001285905,0.002292219],"genre_scores_gemma":[0.002174345,0.9955875,0.000391405,0.0002581483,0.000215612,0.000006219133,0.00002697664,0.000002028317,0.001337805],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003992111,"threshold_uncertainty_score":0.01335496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374170961929225,"score_gpt":0.2972873786330599,"score_spread":0.2735456690137677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}