{"id":"W2145160468","doi":"10.1093/humupd/dmh002","title":"Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology","year":2004,"lang":"en","type":"review","venue":"Human Reproduction Update","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital","funders":"","keywords":"Genomic imprinting; Reprogramming; Biology; Imprinting (psychology); Epigenetics; Germ cell; Genetics; Assisted reproductive technology; Epigenesis; DNA methylation; Infertility; Gene; Pregnancy; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009348795,0.0004635032,0.001024102,0.0003555546,0.0002598942,0.00003817524,0.0002769956,0.0004851425,0.00001002733],"category_scores_gemma":[0.0004288826,0.0004742056,0.000366056,0.0002991327,0.0002902142,0.000007615455,0.0003275833,0.0002684481,0.000007363923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000668764,"about_ca_system_score_gemma":0.000197959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001507781,"about_ca_topic_score_gemma":0.000002107136,"domain_scores_codex":[0.9957666,0.0001053449,0.0009608403,0.002642553,0.0001373857,0.0003872289],"domain_scores_gemma":[0.9964268,0.000006098658,0.001225868,0.00194635,0.0003376138,0.00005725503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001616156,0.00009817406,0.00003041141,0.008811016,0.0003705308,0.000001396676,0.00002362297,0.00004654172,0.2457299,0.0002349647,0.00009827584,0.744539],"study_design_scores_gemma":[0.0008063741,0.0007243942,0.0006314503,0.001952109,0.001262481,0.001550191,0.00008404176,0.000001873847,0.07796788,0.0009694776,0.9129475,0.001102163],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07304315,0.9232262,0.0007498242,0.00007184325,0.0008206989,0.001965216,0.00002535517,0.00006091006,0.00003683666],"genre_scores_gemma":[0.02711406,0.9645232,0.004745174,0.000005425547,0.001754963,0.0003774154,0.0004230902,0.0001523724,0.0009042838],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9128493,"threshold_uncertainty_score":0.9997709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374170961929225,"score_gpt":0.2972873786330599,"score_spread":0.2735456690137677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}